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Gabapentin and Systolic dysfunction - a phase IV clinical study of FDA data

Summary:

Systolic dysfunction is reported as a side effect among people who take Gabapentin (gabapentin), especially for people who are female, 50-59 old, also take Fluoxetine, and have Seizures.

The phase IV clinical study analyzes which people have Systolic dysfunction when taking Gabapentin. It is created by eHealthMe based on reports of 313,421 people who have side effects when taking Gabapentin from the FDA, and is updated regularly.

What is Gabapentin?

Gabapentin has active ingredients of gabapentin. It is often used in peripheral neuropathy. eHealthMe is studying from 322,987 Gabapentin users. Check the latest studies of Gabapentin.

What is Systolic dysfunction?

Systolic dysfunction (impaired ventricular contraction) is found to be associated with 200 drugs and 220 conditions by eHealthMe. Check the latest studies of Systolic dysfunction.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

313,421 people reported to have side effects when taking Gabapentin.
Among them, 28 people (0.01%) have Systolic dysfunction.

Could Gabapentin cause Systolic dysfunction?

Among these 28 people:

What is the gender of people who have Systolic dysfunction when taking Gabapentin? *

  • female: 52 %
  • male: 48 %

What is the age of people who have Systolic dysfunction when taking Gabapentin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 14.29 %
  • 20-29: 0.0 %
  • 30-39: 4.76 %
  • 40-49: 0.0 %
  • 50-59: 52.38 %
  • 60+: 28.57 %

What are other drugs people take besides Gabapentin? *

  1. Fluoxetine: 14 people, 50.00%
  2. Clonidine: 13 people, 46.43%
  3. Magnesium: 5 people, 17.86%
  4. Ondansetron: 5 people, 17.86%
  5. Bupropion Hydrochloride: 5 people, 17.86%
  6. Levetiracetam: 4 people, 14.29%
  7. Vitamin D: 4 people, 14.29%
  8. Vancomycin: 4 people, 14.29%
  9. Zopiclone: 3 people, 10.71%
  10. Prinivil: 3 people, 10.71%

What are other side effects people have besides Systolic dysfunction? *

  1. Electrocardiogram Qt Prolonged: 14 people, 50.00%
  2. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 14 people, 50.00%
  3. Bundle Branch Block Left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle): 13 people, 46.43%
  4. Ejection Fraction Decreased (systolic heart failure): 13 people, 46.43%
  5. Acidosis (build-up of carbon dioxide in the blood): 11 people, 39.29%
  6. Haemodynamic Instability (disturbances in the blood movement in our body): 10 people, 35.71%
  7. Ventricular Hypokinesia (muscle of one's heart does not contract as much as most peoples' hearts do): 9 people, 32.14%
  8. Hypotension (abnormally low blood pressure): 8 people, 28.57%
  9. Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 8 people, 28.57%
  10. Ards (Acute Respiratory Distress Syndrome) (sudden failure of the respiratory (breathing) system): 8 people, 28.57%

What are the existing conditions these people have? *

  1. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 5 people, 17.86%
  2. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 14.29%
  3. Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 3 people, 10.71%
  4. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 10.71%
  5. Mean Arterial Pressure Decreased (less than an average blood pressure in an individual): 3 people, 10.71%
  6. Haemodynamic Instability (disturbances in the blood movement in our body): 3 people, 10.71%
  7. Electrocardiogram Qt Prolonged: 3 people, 10.71%
  8. Drowsiness: 3 people, 10.71%
  9. Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 2 people, 7.14%
  10. Multiple Myeloma (cancer of the plasma cells): 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Gabapentin and have Systolic dysfunction?

- Check whether Systolic dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Gabapentin:

Systolic dysfunction treatments and more:

How severe was Systolic dysfunction and when was it recovered:

Expand to all the drugs that have ingredients of gabapentin:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Gabapentin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Systolic dysfunction:

Browse all the conditions that are associated with Systolic dysfunction:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on gabapentin (the active ingredients of Gabapentin) and Gabapentin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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