Gliclazide and Anion gap increased - a phase IV clinical study of FDA data

Summary:

Anion gap increased is reported as a side effect among people who take Gliclazide (gliclazide), especially for people who are male, 60+ old, also take Metformin, and have Schizophrenia.

The phase IV clinical study analyzes which people have Anion gap increased when taking Gliclazide. It is created by eHealthMe based on reports of 27,903 people who have side effects when taking Gliclazide from the FDA, and is updated regularly.

What is Gliclazide?

Gliclazide has active ingredients of gliclazide. It is often used in diabetes. eHealthMe is studying from 28,131 Gliclazide users. Check the latest studies of Gliclazide.

What is Anion gap increased?

Anion gap increased is found to be associated with 257 drugs and 394 conditions by eHealthMe. Check the latest studies of Anion gap increased.

On Apr, 23, 2026

27,903 people reported to have side effects when taking Gliclazide.
Among them, 24 people (0.09%) have Anion gap increased.

Could Gliclazide cause Anion gap increased?

Among these 24 people:

What is the gender of people who have Anion gap increased when taking Gliclazide? *

female: 31.82 %
male: 68.18 %

What is the age of people who have Anion gap increased when taking Gliclazide? *

What are other drugs people take besides Gliclazide? *

What are other side effects people have besides Anion gap increased? *

Mean Cell Volume Decreased (less of the average red blood cell volume): 7 people, 29.17%
Mean Cell Haemoglobin Decreased (less than normal haemoglobin per red blood cell in a sample of blood): 7 people, 29.17%
Blood Chloride Decreased: 7 people, 29.17%
Blood Glucose Increased: 7 people, 29.17%
Blood Sodium Decreased: 7 people, 29.17%
Neutrophil Count Increased (excess than normal number of neutrophil a type of blood cell): 7 people, 29.17%
Sinus Tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 7 people, 29.17%
Gamma-Glutamyltransferase Increased: 6 people, 25.00%
Malaise (a feeling of general discomfort or uneasiness): 6 people, 25.00%
High Blood Cholesterol: 6 people, 25.00%

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 10 people, 41.67%
High Blood Pressure: 5 people, 20.83%
High Blood Cholesterol: 5 people, 20.83%
Stable Angina (a constant chest pain): 4 people, 16.67%
Psychotic Disorder: 4 people, 16.67%
Constipation: 4 people, 16.67%
Affective Disorder (mental disorder): 4 people, 16.67%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 1 person, 4.17%
Renal Cell Carcinoma (a kidney cancer): 1 person, 4.17%
Gout (uric acid crystals building up in the body): 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Gliclazide and have Anion gap increased?

- Check whether Anion gap increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Gliclazide:

Gliclazide (28,131 reports)

Browse all side effects of Gliclazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Anion gap increased:

Anion gap increased (257 drugs)

Browse all the conditions that are associated with Anion gap increased:

Anion gap increased (394 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on gliclazide (the active ingredients of Gliclazide) and Gliclazide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.