Glucovance and Generalised oedema - a phase IV clinical study of FDA data

Summary:

Generalised oedema is reported as a side effect among people who take Glucovance (glyburide; metformin hydrochloride), especially for people who are male, 60+ old, also take Neurontin, and have Bone disorder.

The phase IV clinical study analyzes which people have Generalised oedema when taking Glucovance. It is created by eHealthMe based on reports of 6,238 people who have side effects when taking Glucovance from the FDA, and is updated regularly.

What is Glucovance?

Glucovance has active ingredients of glyburide; metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 6,302 Glucovance users. Check the latest studies of Glucovance.

What is Generalised oedema?

Generalised oedema (swelling all over the body) is found to be associated with 1,089 drugs and 1,406 conditions by eHealthMe. Check the latest studies of Generalised oedema.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

6,238 people reported to have side effects when taking Glucovance.
Among them, 21 people (0.34%) have Generalised oedema.

Could Glucovance cause Generalised oedema?

Among these 21 people:

What is the gender of people who have Generalised oedema when taking Glucovance? *

female: 14.29 %
male: 85.71 %

What is the age of people who have Generalised oedema when taking Glucovance? *

What are other drugs people take besides Glucovance? *

What are other side effects people have besides Generalised oedema? *

Pneumonia: 18 people, 85.71%
Herpes Zoster: 18 people, 85.71%
Headache (pain in head): 18 people, 85.71%
Injury: 18 people, 85.71%
Stress And Anxiety: 18 people, 85.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 18 people, 85.71%
Back Pain: 18 people, 85.71%
Neck Pain: 18 people, 85.71%
Enlarged Heart: 18 people, 85.71%
Coughing Up Blood: 18 people, 85.71%

What are the existing conditions these people have? *

Bone Disorder: 15 people, 71.43%
Multiple Myeloma (cancer of the plasma cells): 10 people, 47.62%
Pancreatic Carcinoma Metastatic (pancreatic cancer- metastatic): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Glucovance and have Generalised oedema?

- Check whether Generalised oedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Glucovance:

Glucovance (6,302 reports)

Generalised oedema treatments and more:

Generalised oedema (14,751 reports)

How severe was Generalised oedema and when was it recovered:

Generalised oedema in Glucovance

Expand to all the drugs that have ingredients of glyburide; metformin hydrochloride:

Generalised oedema and drugs with ingredients of glyburide; metformin hydrochloride

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Glucovance:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Generalised oedema:

Generalised oedema (1,089 drugs)

Browse all the conditions that are associated with Generalised oedema:

Generalised oedema (1,406 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on glyburide; metformin hydrochloride (the active ingredients of Glucovance) and Glucovance (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.