Glucovance and Sciatica - a phase IV clinical study of FDA data

Summary:

Sciatica is reported as a side effect among people who take Glucovance (glyburide; metformin hydrochloride), especially for people who are female, 60+ old, also take Vioxx, and have Breast cancer.

The phase IV clinical study analyzes which people have Sciatica when taking Glucovance. It is created by eHealthMe based on reports of 6,238 people who have side effects when taking Glucovance from the FDA, and is updated regularly.

What is Glucovance?

Glucovance has active ingredients of glyburide; metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 6,302 Glucovance users. Check the latest studies of Glucovance.

What is Sciatica?

Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve) is found to be associated with 1,137 drugs and 1,433 conditions by eHealthMe. Check the latest studies of Sciatica.

On Apr, 23, 2026

6,238 people reported to have side effects when taking Glucovance.
Among them, 27 people (0.43%) have Sciatica.

Among these 27 people:

What is the gender of people who have Sciatica when taking Glucovance? *

female: 74.07 %
male: 25.93 %

What is the age of people who have Sciatica when taking Glucovance? *

What are other drugs people take besides Glucovance? *

What are other side effects people have besides Sciatica? *

Stress And Anxiety: 21 people, 77.78%
High Blood Cholesterol: 19 people, 70.37%
Pain: 18 people, 66.67%
Back Pain: 18 people, 66.67%
Hypoaesthesia (reduced sense of touch or sensation): 17 people, 62.96%
Pain In Extremity: 17 people, 62.96%
Lumbar Spinal Stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone): 16 people, 59.26%
Weight Decreased: 16 people, 59.26%
Joint Pain: 15 people, 55.56%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 15 people, 55.56%

What are the existing conditions these people have? *

Fungal Infection: 9 people, 33.33%
Breast Cancer: 9 people, 33.33%
Asthma: 3 people, 11.11%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 2 people, 7.41%
Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 2 people, 7.41%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 2 people, 7.41%
Bipolar Disorder (mood disorder): 2 people, 7.41%
Stress And Anxiety: 1 person, 3.70%
Primary Hypothyroidism (failure of the thyroid gland to produce or release thyroid hormones into the bloodstream): 1 person, 3.70%
Pain: 1 person, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Glucovance and have Sciatica?

- Check whether Sciatica is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Glucovance:

Glucovance (6,302 reports)

Sciatica treatments and more:

Sciatica (28,509 reports)

How severe was Sciatica and when was it recovered:

Sciatica in Glucovance

Expand to all the drugs that have ingredients of glyburide; metformin hydrochloride:

Sciatica and drugs with ingredients of glyburide; metformin hydrochloride

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Glucovance:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sciatica:

Sciatica (1,137 drugs)

Browse all the conditions that are associated with Sciatica:

Sciatica (1,433 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on glyburide; metformin hydrochloride (the active ingredients of Glucovance) and Glucovance (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.