Gocovri and Skin discoloration - a phase IV clinical study of FDA data

Summary:

Skin discoloration is reported as a side effect among people who take Gocovri (amantadine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Rytary, and have Dyskinesia.

The phase IV clinical study analyzes which people have Skin discoloration when taking Gocovri. It is created by eHealthMe based on reports of 2,658 people who have side effects when taking Gocovri from the FDA, and is updated regularly.

What is Gocovri?

Gocovri has active ingredients of amantadine hydrochloride. eHealthMe is studying from 2,662 Gocovri users. Check the latest studies of Gocovri.

What is Skin discoloration?

Skin discoloration is found to be associated with 1,713 drugs and 1,590 conditions by eHealthMe. Check the latest studies of Skin discoloration.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

2,658 people reported to have side effects when taking Gocovri.
Among them, 35 people (1.32%) have Skin discoloration.

Among these 35 people:

How long have people been on Gocovri when they have Skin discoloration? *

What is the gender of people who have Skin discoloration when taking Gocovri? *

female: 63.33 %
male: 36.67 %

What is the age of people who have Skin discoloration when taking Gocovri? *

What are other drugs people take besides Gocovri? *

What are other side effects people have besides Skin discoloration? *

Dry Mouth: 9 people, 25.71%
Peripheral Swelling: 8 people, 22.86%
Idiopathic Or Primary Livedo Reticularis (netlike pattern of reddish-blue skin discoloration, usually on the legs): 7 people, 20.00%
Rashes (redness): 7 people, 20.00%
Fall: 6 people, 17.14%
Constipation: 5 people, 14.29%
Gait Disturbance: 4 people, 11.43%
Hallucinations (sensations that appear real but are created by your mind): 4 people, 11.43%
Hallucination, Visual (seeing things that aren't there): 4 people, 11.43%
Sleep Disorder: 4 people, 11.43%

What are the existing conditions these people have? *

Dyskinesia (abnormality or impairment of voluntary movement): 22 people, 62.86%
Parkinson's Disease: 14 people, 40.00%
Hallucinations (sensations that appear real but are created by your mind): 4 people, 11.43%
Delusion (a false belief or opinion): 4 people, 11.43%
On And Off Phenomenon: 2 people, 5.71%
Urinary Tract Infection: 1 person, 2.86%
Peripheral Swelling: 1 person, 2.86%
Neuropathy Peripheral (surface nerve damage): 1 person, 2.86%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 1 person, 2.86%
Infected Cyst: 1 person, 2.86%

* Approximation only. Some reports may have incomplete information.

Do you take Gocovri and have Skin discoloration?

- Check whether Skin discoloration is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Gocovri:

Gocovri (2,662 reports)

Browse all side effects of Gocovri:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Skin discoloration:

Skin discoloration (1,713 drugs)

Browse all the conditions that are associated with Skin discoloration:

Skin discoloration (1,590 conditions)

Related publications that referenced our studies

Yang Y, Teja S, Baig K, "Bilateral corneal edema associated with amantadine", Canadian Medical Association Journal, 2015 Oct .
Cattoni J, Parekh R, "Acute respiratory distress syndrome: A rare presentation of amantadine toxicity", The American journal of case reports, 2012 Jan .
Yang Y, Teja S, Baig K, "Bilateral corneal edema associated with amantadine", Canadian Medical Association Journal, 2015 Oct .
Cattoni J, Parekh R, "Acute respiratory distress syndrome: A rare presentation of amantadine toxicity", The American journal of case reports, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on amantadine hydrochloride (the active ingredients of Gocovri) and Gocovri (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.