Gralise and Sciatica - a phase IV clinical study of FDA data

Summary:

Sciatica is reported as a side effect among people who take Gralise (gabapentin), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Percocet, and have Pain.

The phase IV clinical study analyzes which people have Sciatica when taking Gralise. It is created by eHealthMe based on reports of 4,175 people who have side effects when taking Gralise from the FDA, and is updated regularly.

What is Gralise?

Gralise has active ingredients of gabapentin. It is often used in neuralgia. eHealthMe is studying from 4,282 Gralise users. Check the latest studies of Gralise.

What is Sciatica?

Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve) is found to be associated with 1,144 drugs and 1,429 conditions by eHealthMe. Check the latest studies of Sciatica.

On Mar, 27, 2026

4,175 people reported to have side effects when taking Gralise.
Among them, 6 people (0.14%) have Sciatica.

Among these 6 people:

How long have people been on Gralise when they have Sciatica? *

What is the gender of people who have Sciatica when taking Gralise? *

female: 100 %
male: 0.0 %

What is the age of people who have Sciatica when taking Gralise? *

What are other drugs people take besides Gralise? *

What are other side effects people have besides Sciatica? *

Abdominal Distension: 3 people, 50.00%
Pain: 3 people, 50.00%
Fatigue (feeling of tiredness): 3 people, 50.00%
Weight Increased: 3 people, 50.00%
Incontinence (lack of moderation or self-control): 3 people, 50.00%
Euphoric Mood (excessively happy but may become angry or irritable): 3 people, 50.00%
Malaise (a feeling of general discomfort or uneasiness): 3 people, 50.00%
Memory Loss: 3 people, 50.00%
Drowsiness: 3 people, 50.00%
Nausea (feeling of having an urge to vomit): 3 people, 50.00%

What are the existing conditions these people have? *

High Blood Pressure: 4 people, 66.67%
Pain: 4 people, 66.67%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 3 people, 50.00%
Type 2 Diabetes: 2 people, 33.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 33.33%
High Blood Cholesterol: 1 person, 16.67%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 1 person, 16.67%
Headache (pain in head): 1 person, 16.67%
Glaucoma (increased fluid pressure in the eye with vision loss): 1 person, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Gralise and have Sciatica?

- Check whether Sciatica is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Gralise:

Gralise (4,282 reports)

Sciatica treatments and more:

Sciatica (28,509 reports)

Browse all side effects of Gralise:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sciatica:

Sciatica (1,144 drugs)

Browse all the conditions that are associated with Sciatica:

Sciatica (1,429 conditions)

Related publications that referenced our studies

de Landaluce, L. O., Carbonell, P., Asensio, C., Escoda, N., López, P., & Laporte, J. R. , "Gabapentin and Pregabalin and Risk of Atrial Fibrillation in the Elderly: A Population-Based Cohort Study in an Electronic Prescription Database", Drug safety, 2018 Jan .
Scarff JR, "The Potential for Somnambulism Associated with Gabapentin", The Internet Journal of Psychiatry, 2014 Jan .
de Landaluce, L. O., Carbonell, P., Asensio, C., Escoda, N., López, P., & Laporte, J. R. , "Gabapentin and Pregabalin and Risk of Atrial Fibrillation in the Elderly: A Population-Based Cohort Study in an Electronic Prescription Database", Drug safety, 2018 Jan .
Scarff JR, "The Potential for Somnambulism Associated with Gabapentin", The Internet Journal of Psychiatry, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on gabapentin (the active ingredients of Gralise) and Gralise (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.