Gravol and Splenomegaly - a phase IV clinical study of FDA data

Summary:

Splenomegaly is reported as a side effect among people who take Gravol (dimenhydrinate), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Benadryl, and have Hereditary neuropathic amyloidosis.

The phase IV clinical study analyzes which people have Splenomegaly when taking Gravol. It is created by eHealthMe based on reports of 6,796 people who have side effects when taking Gravol from the FDA, and is updated regularly.

What is Gravol?

Gravol has active ingredients of dimenhydrinate. It is often used in nausea. eHealthMe is studying from 7,193 Gravol users. Check the latest studies of Gravol.

What is Splenomegaly?

Splenomegaly (enlargement of spleen) is found to be associated with 1,103 drugs and 1,477 conditions by eHealthMe. Check the latest studies of Splenomegaly.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

6,796 people reported to have side effects when taking Gravol.
Among them, 20 people (0.29%) have Splenomegaly.

Among these 20 people:

How long have people been on Gravol when they have Splenomegaly? *

What is the gender of people who have Splenomegaly when taking Gravol? *

female: 17.65 %
male: 82.35 %

What is the age of people who have Splenomegaly when taking Gravol? *

What are other drugs people take besides Gravol? *

What are other side effects people have besides Splenomegaly? *

Fatigue (feeling of tiredness): 10 people, 50.00%
Urticaria (rash of round, red welts on the skin that itch intensely): 9 people, 45.00%
Blood Creatine Phosphokinase Increased: 7 people, 35.00%
Drowsiness: 6 people, 30.00%
Urinary Tract Infection: 6 people, 30.00%
Headache (pain in head): 6 people, 30.00%
Pleural Effusion (water on the lungs): 5 people, 25.00%
Prealbumin Decreased: 5 people, 25.00%
Constipation: 5 people, 25.00%
Oropharyngeal Pain: 5 people, 25.00%

What are the existing conditions these people have? *

Hereditary Neuropathic Amyloidosis (hereditary- diseases resulting from abnormal deposition of certain proteins (amyloid) in various bodily areas by problems with signals from the nerves): 5 people, 25.00%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 20.00%
Primary Myelofibrosis (primary disorder of the bone marrow): 3 people, 15.00%
Infection: 2 people, 10.00%
Hepatitis C: 2 people, 10.00%
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 1 person, 5.00%
Oral Herpes (viral infection of mouth): 1 person, 5.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.00%
Diarrhea: 1 person, 5.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Gravol and have Splenomegaly?

- Check whether Splenomegaly is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Gravol:

Gravol (7,193 reports)

Splenomegaly treatments and more:

Splenomegaly (17,257 reports)

Browse all side effects of Gravol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Splenomegaly:

Splenomegaly (1,103 drugs)

Browse all the conditions that are associated with Splenomegaly:

Splenomegaly (1,477 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on dimenhydrinate (the active ingredients of Gravol) and Gravol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.