Haloperidol and Hyperreflexia - a phase IV clinical study of FDA data

Summary:

Hyperreflexia is reported as a side effect among people who take Haloperidol (haloperidol), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Olanzapine, and have Mania.

The phase IV clinical study analyzes which people have Hyperreflexia when taking Haloperidol. It is created by eHealthMe based on reports of 16,432 people who have side effects when taking Haloperidol from the FDA, and is updated regularly.

What is Haloperidol?

Haloperidol has active ingredients of haloperidol. It is often used in schizophrenia. eHealthMe is studying from 16,637 Haloperidol users. Check the latest studies of Haloperidol.

What is Hyperreflexia?

Hyperreflexia (overactive or over responsive reflexes) is found to be associated with 432 drugs and 649 conditions by eHealthMe. Check the latest studies of Hyperreflexia.

On Jun, 20, 2026

16,432 people reported to have side effects when taking Haloperidol.
Among them, 70 people (0.43%) have Hyperreflexia.

Among these 70 people:

How long have people been on Haloperidol when they have Hyperreflexia? *

What is the gender of people who have Hyperreflexia when taking Haloperidol? *

female: 53.03 %
male: 46.97 %

What is the age of people who have Hyperreflexia when taking Haloperidol? *

What are other drugs people take besides Haloperidol? *

Olanzapine: 12 people, 17.14%
Aripiprazole: 7 people, 10.00%
Clonazepam: 6 people, 8.57%
Erythromycin: 6 people, 8.57%
Benztropine Mesylate: 5 people, 7.14%
Lithium Carbonate: 5 people, 7.14%
Fluoxetine: 5 people, 7.14%
Morphine: 4 people, 5.71%
Lorazepam: 4 people, 5.71%
Citalopram Hydrobromide: 4 people, 5.71%

What are other side effects people have besides Hyperreflexia? *

Fever: 30 people, 42.86%
Tremor (trembling or shaking movements in one or more parts of your body): 29 people, 41.43%
Hyperhidrosis (abnormally increased sweating): 25 people, 35.71%
Depressed Level Of Consciousness: 24 people, 34.29%
Muscle Rigidity (muscle stiffness): 24 people, 34.29%
Clonus (series of involuntary, rhythmic, muscular contractions and relaxations): 24 people, 34.29%
Neuroleptic Malignant Syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents): 20 people, 28.57%
Blood Creatine Phosphokinase Increased: 20 people, 28.57%
Agitation (state of anxiety or nervous excitement): 17 people, 24.29%
Movement - Uncontrolled Or Slow: 17 people, 24.29%

What are the existing conditions these people have? *

Cervical Spinal Stenosis (narrowing of the spinal canal in the neck): 7 people, 10.00%
Delirium (wild excitement): 7 people, 10.00%
Mania (a state of abnormally elevated or irritable mood): 7 people, 10.00%
Upper Respiratory Tract Infection: 6 people, 8.57%
Accidental Exposure: 6 people, 8.57%
Agitation (state of anxiety or nervous excitement): 6 people, 8.57%
Depression: 5 people, 7.14%
Lung Cancer - Non-Small Cell (lung cancer): 3 people, 4.29%
Diabetes Insipidus (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function): 3 people, 4.29%
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 3 people, 4.29%

* Approximation only. Some reports may have incomplete information.

Do you take Haloperidol and have Hyperreflexia?

- Check whether Hyperreflexia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Haloperidol:

Haloperidol (16,637 reports)

Hyperreflexia treatments and more:

Hyperreflexia (4,677 reports)

Browse all side effects of Haloperidol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperreflexia:

Hyperreflexia (432 drugs)

Browse all the conditions that are associated with Hyperreflexia:

Hyperreflexia (649 conditions)

Related publications that referenced our studies

Obayi, O., & Tagbo, N. , "Bilateral Pedal Oedema Associated with Intramuscular Haloperidol–A Rare Observation", International Neuropsychiatric Disease Journal, 2018 Jan .
Obayi, O., & Tagbo, N. , "Bilateral Pedal Oedema Associated with Intramuscular Haloperidol–A Rare Observation", International Neuropsychiatric Disease Journal, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on haloperidol (the active ingredients of Haloperidol) and Haloperidol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.