Harpagophytum procumbens and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Harpagophytum procumbens (devil's claw), especially for people who are female, 60+ old, also take Chondroitin, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Headache when taking Harpagophytum procumbens. It is created by eHealthMe based on reports of 90 people who have side effects when taking Harpagophytum procumbens from the FDA, and is updated regularly.

What is Harpagophytum procumbens?

Harpagophytum procumbens has active ingredients of devil's claw. eHealthMe is studying from 90 Harpagophytum procumbens users. Check the latest studies of Harpagophytum procumbens.

What is Headache?

Headache (pain in head) is found to be associated with 3,754 drugs and 5,775 conditions by eHealthMe. Check the latest studies of Headache.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

90 people reported to have side effects when taking Harpagophytum procumbens.
Among them, 11 people (12.22%) have Headache.

Could Harpagophytum procumbens cause Headache?

Among these 11 people:

What is the gender of people who have Headache when taking Harpagophytum procumbens? *

female: 100 %
male: 0.0 %

What is the age of people who have Headache when taking Harpagophytum procumbens? *

What are other drugs people take besides Harpagophytum procumbens? *

What are other side effects people have besides Headache? *

Pain: 10 people, 90.91%
Nausea (feeling of having an urge to vomit): 9 people, 81.82%
Dizziness: 8 people, 72.73%
Fatigue (feeling of tiredness): 7 people, 63.64%
Weight Decreased: 6 people, 54.55%
Weakness: 6 people, 54.55%
Bone Disorder: 6 people, 54.55%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 6 people, 54.55%
Joint Swelling: 6 people, 54.55%
Joint Pain: 6 people, 54.55%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 72.73%
Pain: 7 people, 63.64%
High Blood Pressure: 7 people, 63.64%
Joint Swelling: 6 people, 54.55%
Primary Myelofibrosis (primary disorder of the bone marrow): 2 people, 18.18%
Thyroid Diseases: 1 person, 9.09%
Osteoporosis (bones weak and more likely to break): 1 person, 9.09%
Nausea And Vomiting: 1 person, 9.09%
Labyrinthitis (inflammation of the labyrinth or inner ear): 1 person, 9.09%
Gastric Disorder (disease of stomach): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Harpagophytum procumbens and have Headache?

- Check whether Headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Harpagophytum procumbens:

Harpagophytum procumbens (90 reports)

Headache treatments and more:

Headache (756,642 reports)

Browse all side effects of Harpagophytum procumbens:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Headache:

Headache (3,754 drugs)

Browse all the conditions that are associated with Headache:

Headache (5,775 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on devil's claw (the active ingredients of Harpagophytum procumbens) and Harpagophytum procumbens (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.