Hepsera and Aseptic necrosis - a phase IV clinical study of FDA data

Summary:

Aseptic necrosis is reported as a side effect among people who take Hepsera (adefovir dipivoxil), especially for people who are male, 50-59 old, have been taking the drug for 5 - 10 years also take Lamivudine, and have Acquired immunodeficiency syndrome.

The phase IV clinical study analyzes which people have Aseptic necrosis when taking Hepsera. It is created by eHealthMe based on reports of 3,102 people who have side effects when taking Hepsera from the FDA, and is updated regularly.

What is Hepsera?

Hepsera has active ingredients of adefovir dipivoxil. It is often used in hepatitis b. eHealthMe is studying from 3,113 Hepsera users. Check the latest studies of Hepsera.

What is Aseptic necrosis?

Aseptic necrosis (the death of bone tissue due to a lack of blood supply) is found to be associated with 1,347 drugs and 1,695 conditions by eHealthMe. Check the latest studies of Aseptic necrosis.

On Jul, 29, 2026

3,102 people reported to have side effects when taking Hepsera.
Among them, 30 people (0.97%) have Aseptic necrosis.

Among these 30 people:

How long have people been on Hepsera when they have Aseptic necrosis? *

What is the gender of people who have Aseptic necrosis when taking Hepsera? *

female: 10.71 %
male: 89.29 %

What is the age of people who have Aseptic necrosis when taking Hepsera? *

What are other drugs people take besides Hepsera? *

What are other side effects people have besides Aseptic necrosis? *

Fanconi Syndrome Acquired (self developed genetic disease of kidney damage due to defective transport system): 19 people, 63.33%
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood): 16 people, 53.33%
Osteoporosis (bones weak and more likely to break): 15 people, 50.00%
Renal Impairment (severely reduced kidney function): 12 people, 40.00%
Joint Pain: 11 people, 36.67%
Blood Creatinine Increased: 10 people, 33.33%
Rib Fracture: 10 people, 33.33%
Gait Disturbance: 10 people, 33.33%
Renal Tubular Disorder (disease of kidney tubules): 10 people, 33.33%
Osteomalacia (softening of the bones due to a lack of vitamin d): 9 people, 30.00%

What are the existing conditions these people have? *

Hiv Infection: 2 people, 6.67%
Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 2 people, 6.67%
Acquired Immunodeficiency Syndrome (disease of the human immune system caused by the human immunodeficiency virus (hiv)): 2 people, 6.67%
Partial Seizures (seizures which affect only a part of the brain at onset): 1 person, 3.33%
Neuralgia (pain in one or more nerves): 1 person, 3.33%
Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 1 person, 3.33%
High Blood Pressure: 1 person, 3.33%
Headache (pain in head): 1 person, 3.33%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 3.33%
Diabetes: 1 person, 3.33%

* Approximation only. Some reports may have incomplete information.

Do you take Hepsera and have Aseptic necrosis?

- Check whether Aseptic necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hepsera:

Hepsera (3,113 reports)

Aseptic necrosis treatments and more:

Aseptic necrosis (59,829 reports)

Browse all side effects of Hepsera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aseptic necrosis:

Aseptic necrosis (1,347 drugs)

Browse all the conditions that are associated with Aseptic necrosis:

Aseptic necrosis (1,695 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on adefovir dipivoxil (the active ingredients of Hepsera) and Hepsera (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.