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Hepsera and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Hepsera (adefovir dipivoxil), especially for people who are male, 60+ old, have been taking the drug for 1 - 2 years also take Norvasc, and have High blood pressure.

The phase IV clinical study analyzes which people have Headache when taking Hepsera. It is created by eHealthMe based on reports of 3,102 people who have side effects when taking Hepsera from the FDA, and is updated regularly.

What is Hepsera?

Hepsera has active ingredients of adefovir dipivoxil. It is often used in hepatitis b. eHealthMe is studying from 3,113 Hepsera users. Check the latest studies of Hepsera.

What is Headache?

Headache (pain in head) is found to be associated with 3,751 drugs and 5,772 conditions by eHealthMe. Check the latest studies of Headache.

On Jul, 19, 2026

3,102 people reported to have side effects when taking Hepsera.
Among them, 46 people (1.48%) have Headache.

Could Hepsera cause Headache?

Among these 46 people:

How long have people been on Hepsera when they have Headache? *

  • < 1 month: 11.11 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 44.44 %
  • 2 - 5 years: 33.33 %
  • 5 - 10 years: 11.11 %
  • 10+ years: 0.0 %

What is the gender of people who have Headache when taking Hepsera? *

  • female: 13.04 %
  • male: 86.96 %

What is the age of people who have Headache when taking Hepsera? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 5.41 %
  • 30-39: 16.22 %
  • 40-49: 18.92 %
  • 50-59: 18.92 %
  • 60+: 40.54 %

What are other drugs people take besides Hepsera? *

  1. Norvasc: 12 people, 26.09%
  2. Viread: 9 people, 19.57%
  3. Advil: 2 people, 4.35%
  4. Urso 250: 1 person, 2.17%
  5. Tenofovir Disoproxil Fumarate: 1 person, 2.17%
  6. Lamivudine: 1 person, 2.17%
  7. Lamictal: 1 person, 2.17%
  8. Glycyrrhiza Glabra: 1 person, 2.17%
  9. Forteo: 1 person, 2.17%
  10. Entecavir: 1 person, 2.17%

What are other side effects people have besides Headache? *

  1. Back Pain: 14 people, 30.43%
  2. Splenomegaly (enlargement of spleen): 12 people, 26.09%
  3. Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 12 people, 26.09%
  4. Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 12 people, 26.09%
  5. High Blood Pressure: 12 people, 26.09%
  6. Lacunar Infarction (a type of stroke): 12 people, 26.09%
  7. Osteomalacia (softening of the bones due to a lack of vitamin d): 8 people, 17.39%
  8. Confusional State: 7 people, 15.22%
  9. Disease Recurrence: 6 people, 13.04%
  10. Neck Pain: 6 people, 13.04%

What are the existing conditions these people have? *

  1. Insomnia (sleeplessness): 12 people, 26.09%
  2. High Blood Pressure: 12 people, 26.09%
  3. Acquired Immunodeficiency Syndrome (disease of the human immune system caused by the human immunodeficiency virus (hiv)): 2 people, 4.35%
  4. Arrhythmias (irregular heartbeat): 1 person, 2.17%

* Approximation only. Some reports may have incomplete information.

Do you take Hepsera and have Headache?

- Check whether Headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hepsera:

Headache treatments and more:

How severe was Headache and when was it recovered:

Expand to all the drugs that have ingredients of adefovir dipivoxil:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hepsera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Headache:

Browse all the conditions that are associated with Headache:

How the study uses the data?

The study uses data from the FDA. It is based on adefovir dipivoxil (the active ingredients of Hepsera) and Hepsera (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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