Hibiclens and Encephalopathy - a phase IV clinical study of FDA data

Summary:

Encephalopathy is reported as a side effect among people who take Hibiclens (chlorhexidine gluconate), especially for people who are male, 50-59 old, have been taking the drug for 2 - 5 years also take Lactulose, and have Cataplexy.

The phase IV clinical study analyzes which people have Encephalopathy when taking Hibiclens. It is created by eHealthMe based on reports of 527 people who have side effects when taking Hibiclens from the FDA, and is updated regularly.

What is Hibiclens?

Hibiclens has active ingredients of chlorhexidine gluconate. eHealthMe is studying from 536 Hibiclens users. Check the latest studies of Hibiclens.

What is Encephalopathy?

Encephalopathy (functioning of the brain is affected by some agent or condition) is found to be associated with 1,459 drugs and 1,606 conditions by eHealthMe. Check the latest studies of Encephalopathy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

527 people reported to have side effects when taking Hibiclens.
Among them, 11 people (2.09%) have Encephalopathy.

Among these 11 people:

How long have people been on Hibiclens when they have Encephalopathy? *

What is the gender of people who have Encephalopathy when taking Hibiclens? *

female: 0.0 %
male: 100 %

What is the age of people who have Encephalopathy when taking Hibiclens? *

What are other drugs people take besides Hibiclens? *

Zofran: 10 people, 90.91%
Morphine: 10 people, 90.91%
Bumex: 10 people, 90.91%
Lactulose: 10 people, 90.91%
Zolpidem: 9 people, 81.82%
Isosorbide Mononitrate: 9 people, 81.82%
Famotidine: 9 people, 81.82%
Fluconazole: 9 people, 81.82%
Glucagon: 9 people, 81.82%
Glucophage: 9 people, 81.82%

What are other side effects people have besides Encephalopathy? *

Acute Kidney Failure: 10 people, 90.91%
Septic Shock (shock due to blood infection): 10 people, 90.91%
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid): 9 people, 81.82%
Cardiac Output Decreased: 9 people, 81.82%
Haematoma (collection of blood outside the blood vessels): 9 people, 81.82%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 9 people, 81.82%
Cerebellar Ischaemia (lack of blood supply to cerebeller): 9 people, 81.82%
Cardiogenic Shock (inadequate circulation of blood): 9 people, 81.82%
Hepatic Failure (liver failure): 9 people, 81.82%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 9 people, 81.82%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 9.09%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 1 person, 9.09%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Hibiclens and have Encephalopathy?

- Check whether Encephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hibiclens:

Hibiclens (536 reports)

Encephalopathy treatments and more:

Encephalopathy (27,832 reports)

Browse all side effects of Hibiclens:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Encephalopathy:

Encephalopathy (1,459 drugs)

Browse all the conditions that are associated with Encephalopathy:

Encephalopathy (1,606 conditions)

Related publications that referenced our studies

Kapoor A, Kumar V, Beniwal S, Dutta S, Goyal S, Kumar HS, "Posterior reversible encephalopathy syndrome in non-Hodgkin's lymphoma: Not necessarily reversible!", Clinical Cancer Investigation Journal, 2015 Mar .
Kapoor A, Kumar V, Beniwal S, Dutta S, Goyal S, Kumar HS, "Posterior reversible encephalopathy syndrome in non-Hodgkin's lymphoma: Not necessarily reversible!", Clinical Cancer Investigation Journal, 2015 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on chlorhexidine gluconate (the active ingredients of Hibiclens) and Hibiclens (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.