Hiprex and Multiple sclerosis - a phase IV clinical study of FDA data

Summary:

Multiple sclerosis is reported as a side effect among people who take Hiprex (methenamine hippurate), especially for people who are female, 60+ old, also take Tecfidera, and have Escherichia urinary tract infection.

The phase IV clinical study analyzes which people have Multiple sclerosis when taking Hiprex. It is created by eHealthMe based on reports of 812 people who have side effects when taking Hiprex from the FDA, and is updated regularly.

What is Hiprex?

Hiprex has active ingredients of methenamine hippurate. It is often used in urinary tract infection. eHealthMe is studying from 900 Hiprex users. Check the latest studies of Hiprex.

What is Multiple sclerosis?

Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath) is found to be associated with 1,088 drugs and 1,360 conditions by eHealthMe. Check the latest studies of Multiple sclerosis.

On Jul, 11, 2026

812 people reported to have side effects when taking Hiprex.
Among them, 20 people (2.46%) have Multiple sclerosis.

Among these 20 people:

What is the gender of people who have Multiple sclerosis when taking Hiprex? *

female: 75 %
male: 25 %

What is the age of people who have Multiple sclerosis when taking Hiprex? *

What are other drugs people take besides Hiprex? *

What are other side effects people have besides Multiple sclerosis? *

Infection: 5 people, 25.00%
Drug Ineffective: 4 people, 20.00%
Drowsiness: 4 people, 20.00%
Malaise (a feeling of general discomfort or uneasiness): 4 people, 20.00%
Pneumonia Aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 3 people, 15.00%
Burning Sensation: 3 people, 15.00%
Weakness: 3 people, 15.00%
Nasopharyngitis (inflammation of the nasopharynx): 3 people, 15.00%
Cellulitis (infection under the skin): 3 people, 15.00%
Thinking Abnormal: 3 people, 15.00%

What are the existing conditions these people have? *

Pain: 3 people, 15.00%
Thinking Abnormal: 3 people, 15.00%
Escherichia Urinary Tract Infection (urinary tract infection by escherichia coli): 3 people, 15.00%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 10.00%
Swelling: 2 people, 10.00%
Sleep Disorder: 2 people, 10.00%
Constipation: 2 people, 10.00%
Dyspnea (difficult or laboured breathing): 2 people, 10.00%
Gastric Ulcer (stomach ulcer): 2 people, 10.00%
Gait Disturbance: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Hiprex and have Multiple sclerosis?

- Check whether Multiple sclerosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hiprex:

Hiprex (900 reports)

Browse all side effects of Hiprex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Multiple sclerosis:

Multiple sclerosis (1,088 drugs)

Browse all the conditions that are associated with Multiple sclerosis:

Multiple sclerosis (1,360 conditions)

Related publications that referenced our studies

Christopher KL, Elner VM, Demirci H, "Conjunctival Lymphoma in a Patient on Fingolimod for Relapsing-Remitting Multiple Sclerosis", Ophthalmic Plastic & Reconstructive Surgery, 2017 May .
Christopher, K. L., Elner, V. M., & Demirci, H. , "Conjunctival lymphoma in a patient on fingolimod for relapsing-remitting multiple sclerosis", Ophthalmic plastic and reconstructive surgery , 2014 Jan .
Christopher KL, Elner VM, Demirci H, "Conjunctival Lymphoma in a Patient on Fingolimod for Relapsing-Remitting Multiple Sclerosis", Ophthalmic Plastic & Reconstructive Surgery, 2017 May .
Christopher, K. L., Elner, V. M., & Demirci, H. , "Conjunctival lymphoma in a patient on fingolimod for relapsing-remitting multiple sclerosis", Ophthalmic plastic and reconstructive surgery , 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on methenamine hippurate (the active ingredients of Hiprex) and Hiprex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.