Hizentra and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Hizentra (human immunoglobulin g), especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years also take Epipen, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Hizentra. It is created by eHealthMe based on reports of 23,644 people who have side effects when taking Hizentra from the FDA, and is updated regularly.

What is Hizentra?

Hizentra has active ingredients of human immunoglobulin g. eHealthMe is studying from 23,666 Hizentra users. Check the latest studies of Hizentra.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 946 drugs and 1,232 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 02, 2026

23,644 people reported to have side effects when taking Hizentra.
Among them, 25 people (0.11%) have Knee joint replacement.

Could Hizentra cause Knee joint replacement?

Among these 25 people:

How long have people been on Hizentra when they have Knee joint replacement? *

What is the gender of people who have Knee joint replacement when taking Hizentra? *

female: 79.17 %
male: 20.83 %

What is the age of people who have Knee joint replacement when taking Hizentra? *

What are other drugs people take besides Hizentra? *

What are other side effects people have besides Knee joint replacement? *

Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 20.00%
Joint Pain: 5 people, 20.00%
Weakness: 3 people, 12.00%
Malaise (a feeling of general discomfort or uneasiness): 3 people, 12.00%
Fatigue (feeling of tiredness): 3 people, 12.00%
Nasopharyngitis (inflammation of the nasopharynx): 3 people, 12.00%
Upper Respiratory Tract Infection: 2 people, 8.00%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 2 people, 8.00%
Postoperative Wound Infection: 2 people, 8.00%
Discomfort: 2 people, 8.00%

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 10 people, 40.00%
Primary Immunodeficiency Syndrome: 4 people, 16.00%
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord): 4 people, 16.00%
Immunodeficiency: 2 people, 8.00%
Secondary Immunodeficiency (lack of immunity due to some disease): 1 person, 4.00%
Joint Pain: 1 person, 4.00%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 1 person, 4.00%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 1 person, 4.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Hizentra and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hizentra:

Hizentra (23,666 reports)

Browse all side effects of Hizentra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (946 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,232 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on human immunoglobulin g (the active ingredients of Hizentra) and Hizentra (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.