Humalog and Ddd - a phase IV clinical study of FDA data

Summary:

Ddd is reported as a side effect among people who take Humalog (insulin lispro recombinant), especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years also take Lantus, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Ddd when taking Humalog. It is created by eHealthMe based on reports of 136,521 people who have side effects when taking Humalog from the FDA, and is updated regularly.

What is Humalog?

Humalog has active ingredients of insulin lispro recombinant. It is often used in diabetes. eHealthMe is studying from 137,125 Humalog users. Check the latest studies of Humalog.

What is Ddd?

Ddd is found to be associated with 1,412 drugs and 1,390 conditions by eHealthMe. Check the latest studies of Ddd.



On Oct, 15, 2025

136,521 people reported to have side effects when taking Humalog.
Among them, 142 people (0.1%) have Ddd.

Could Humalog cause Ddd?

Among these 142 people:

How long have people been on Humalog when they have Ddd? *

  • < 1 month: 22.22 %
  • 1 - 6 months: 33.33 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 11.11 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 33.33 %
  • 10+ years: 0.0 %

What is the gender of people who have Ddd when taking Humalog? *

  • female: 61.43 %
  • male: 38.57 %

What is the age of people who have Ddd when taking Humalog? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 1.12 %
  • 40-49: 16.85 %
  • 50-59: 37.08 %
  • 60+: 44.94 %

What are other drugs people take besides Humalog? *

  1. Lantus: 62 people, 43.66%
  2. Lasix: 31 people, 21.83%
  3. Neurontin: 28 people, 19.72%
  4. Lisinopril: 23 people, 16.20%
  5. Aredia: 22 people, 15.49%
  6. Aspirin: 21 people, 14.79%
  7. Nexium: 21 people, 14.79%
  8. Velcade: 20 people, 14.08%
  9. Metformin: 19 people, 13.38%
  10. Plavix: 18 people, 12.68%

What are other side effects people have besides Ddd? *

  1. Pain: 47 people, 33.10%
  2. Blood Glucose Increased: 41 people, 28.87%
  3. Fall: 35 people, 24.65%
  4. Neuropathy Peripheral (surface nerve damage): 31 people, 21.83%
  5. Anaemia (lack of blood): 30 people, 21.13%
  6. Stress And Anxiety: 29 people, 20.42%
  7. Intervertebral Disc Protrusion (spinal disc protrusion): 28 people, 19.72%
  8. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 28 people, 19.72%
  9. Injury: 28 people, 19.72%
  10. Joint Pain: 28 people, 19.72%

What are the existing conditions these people have? *

  1. Pain: 19 people, 13.38%
  2. Multiple Myeloma (cancer of the plasma cells): 19 people, 13.38%
  3. High Blood Cholesterol: 11 people, 7.75%
  4. Depression: 9 people, 6.34%
  5. High Blood Pressure: 9 people, 6.34%
  6. Metastases To Bone (cancer spreads to bone): 8 people, 5.63%
  7. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 5.63%
  8. Hypercalcaemia (elevated calcium (ca+) level in the blood): 8 people, 5.63%
  9. Osteoporosis (bones weak and more likely to break): 6 people, 4.23%
  10. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 5 people, 3.52%

* Approximation only. Some reports may have incomplete information.

Do you take Humalog and have Ddd?

- Check whether Ddd is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Humalog:

Ddd treatments and more:

  • Ddd (19,905 reports)

How severe was Ddd and when was it recovered:

Expand to all the drugs that have ingredients of insulin lispro recombinant:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Humalog side effects:

Browse all side effects of Humalog:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Ddd:

Browse all the drugs that are associated with Ddd:

  • Ddd (1,412 drugs)

Common conditions associated with Ddd:

Browse all the conditions that are associated with Ddd:

  • Ddd (1,390 conditions)

Drugs similar to Humalog and Ddd :


How the study uses the data?

The study uses data from the FDA. It is based on insulin lispro recombinant (the active ingredients of Humalog) and Humalog (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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