Humira and Complement factor c3 increased - a phase IV clinical study of FDA data

Summary:

Complement factor c3 increased is reported as a side effect among people who take Humira (adalimumab), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Orencia, and have Pain.

The phase IV clinical study analyzes which people have Complement factor c3 increased when taking Humira. It is created by eHealthMe based on reports of 758,421 people who have side effects when taking Humira from the FDA, and is updated regularly.

What is Humira?

Humira has active ingredients of adalimumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 761,393 Humira users. Check the latest studies of Humira.

What is Complement factor c3 increased?

Complement factor c3 increased is found to be associated with 15 drugs and 95 conditions by eHealthMe. Check the latest studies of Complement factor c3 increased.

On Jan, 14, 2026

758,421 people reported to have side effects when taking Humira.
Among them, 15 people (0.0%) have Complement factor c3 increased.

Could Humira cause Complement factor c3 increased?

Among these 15 people:

How long have people been on Humira when they have Complement factor c3 increased? *

What is the gender of people who have Complement factor c3 increased when taking Humira? *

female: 86.67 %
male: 13.33 %

What is the age of people who have Complement factor c3 increased when taking Humira? *

What are other drugs people take besides Humira? *

Xeljanz Xr: 6 people, 40.00%
Ultracet: 6 people, 40.00%
Enbrel: 6 people, 40.00%
Kineret: 6 people, 40.00%
Requip: 6 people, 40.00%
Ondansetron: 6 people, 40.00%
Orencia: 6 people, 40.00%
Hydrocodone: 5 people, 33.33%
Keflex: 5 people, 33.33%
Pilocarpine Hydrochloride: 4 people, 26.67%

What are other side effects people have besides Complement factor c3 increased? *

Complement Factor C4 Increased: 9 people, 60.00%
Diarrhea: 9 people, 60.00%
Gait Disturbance: 7 people, 46.67%
Pain: 7 people, 46.67%
Dysstasia (difficulty in standing): 7 people, 46.67%
Limb Injury: 6 people, 40.00%
Nausea (feeling of having an urge to vomit): 6 people, 40.00%
Pelvic Discomfort: 6 people, 40.00%
Oedema Peripheral (superficial swelling): 6 people, 40.00%
Drug Ineffective: 6 people, 40.00%

What are the existing conditions these people have? *

Pain: 5 people, 33.33%
Stress Urinary Incontinence (leak urine with things like coughing, sneezing or exercise): 4 people, 26.67%
Spinal Pain (pain in spine): 3 people, 20.00%
Arthropathy: 3 people, 20.00%
Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 20.00%
Tremor (trembling or shaking movements in one or more parts of your body): 1 person, 6.67%
Thyroid Pain (pain in neck): 1 person, 6.67%
Polyarthritis (arthritis which involves 5 or more joints simultaneously): 1 person, 6.67%
Micturition Disorder (disease of passing urine): 1 person, 6.67%
High Blood Pressure: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Humira and have Complement factor c3 increased?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Humira:

Humira (761,393 reports)

Browse all side effects of Humira:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Complement factor c3 increased:

Complement factor c3 increased (15 drugs)

Browse all the conditions that are associated with Complement factor c3 increased:

Complement factor c3 increased (95 conditions)

Drugs similar to Humira and Complement factor c3 increased :

Related publications that referenced our studies

Chiriac A, Brzezinski P, Stolnicu S, Podoleanu C, Moldovan C, Molnar C, Taranu T, "Eosinophilia–A rare possible adverse reaction during anti-tumor necrosis factor-alpha therapy for psoriasis", Journal of Dermatological Treatment, 2016 Mar .
Chiriac A, Brzezinski P, Stolnicu S, Podoleanu C, Moldovan C, Molnar C, Taranu T, "Eosinophilia–A rare possible adverse reaction during anti-tumor necrosis factor-alpha therapy for psoriasis", Journal of Dermatological Treatment, 2016 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on adalimumab (the active ingredients of Humira) and Humira (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.