Hycodan and Mental status changes - a phase IV clinical study of FDA data

Summary:

Mental status changes is reported as a side effect among people who take Hycodan (homatropine methylbromide; hydrocodone bitartrate), especially for people who are female, 60+ old, also take Neurontin, and have Nausea.

The phase IV clinical study analyzes which people have Mental status changes when taking Hycodan. It is created by eHealthMe based on reports of 713 people who have side effects when taking Hycodan from the FDA, and is updated regularly.

What is Hycodan?

Hycodan has active ingredients of homatropine methylbromide; hydrocodone bitartrate. It is often used in cough. eHealthMe is studying from 769 Hycodan users. Check the latest studies of Hycodan.

What is Mental status changes?

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation) is found to be associated with 1,498 drugs and 1,759 conditions by eHealthMe. Check the latest studies of Mental status changes.

On Jul, 11, 2026

713 people reported to have side effects when taking Hycodan.
Among them, 25 people (3.51%) have Mental status changes.

Could Hycodan cause Mental status changes?

Among these 25 people:

What is the gender of people who have Mental status changes when taking Hycodan? *

female: 77.78 %
male: 22.22 %

What is the age of people who have Mental status changes when taking Hycodan? *

What are other drugs people take besides Hycodan? *

What are other side effects people have besides Mental status changes? *

Confusional State: 19 people, 76.00%
Fatigue (feeling of tiredness): 18 people, 72.00%
Muscle Twitching: 18 people, 72.00%
Weight Increased: 17 people, 68.00%
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 17 people, 68.00%
Pain: 17 people, 68.00%
Nausea (feeling of having an urge to vomit): 17 people, 68.00%
Weakness: 17 people, 68.00%
Insomnia (sleeplessness): 17 people, 68.00%
High Blood Pressure: 17 people, 68.00%

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 18 people, 72.00%
Depression: 17 people, 68.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 16 people, 64.00%
Sleep Disorder: 16 people, 64.00%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 16 people, 64.00%
Muscle Spasms (muscle contraction): 16 people, 64.00%
Multiple Myeloma (cancer of the plasma cells): 3 people, 12.00%
Insomnia (sleeplessness): 2 people, 8.00%
Pain: 2 people, 8.00%
Pneumonia: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

Do you take Hycodan and have Mental status changes?

- Check whether Mental status changes is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hycodan:

Hycodan (769 reports)

Mental status changes treatments and more:

Mental status changes (32,338 reports)

How severe was Mental status changes and when was it recovered:

Mental status changes in Hycodan

Expand to all the drugs that have ingredients of homatropine methylbromide; hydrocodone bitartrate:

Mental status changes and drugs with ingredients of homatropine methylbromide; hydrocodone bitartrate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hycodan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mental status changes:

Mental status changes (1,498 drugs)

Browse all the conditions that are associated with Mental status changes:

Mental status changes (1,759 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on homatropine methylbromide; hydrocodone bitartrate (the active ingredients of Hycodan) and Hycodan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.