Hydramine and Ear buzzing - a phase IV clinical study of FDA data
Summary:
Ear buzzing is reported as a side effect among people who take Hydramine (diphenhydramine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Acetaminophen, and have Rheumatoid arthritis.
The phase IV clinical study analyzes which people have Ear buzzing when taking Hydramine. It is created by eHealthMe based on reports of 113,450 people who have side effects when taking Hydramine from the FDA, and is updated regularly.
What is Hydramine?
Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,898 Hydramine users. Check the latest studies of Hydramine.
What is Ear buzzing?
Ear buzzing is found to be associated with 2,439 drugs and 3,078 conditions by eHealthMe. Check the latest studies of Ear buzzing.
113,450 people reported to have side effects when taking Hydramine.
Among them, 361 people (0.32%) have Ear buzzing.

Among these 361 people:
How long have people been on Hydramine when they have Ear buzzing? *
- < 1 month: 65.38 %
- 1 - 6 months: 3.85 %
- 6 - 12 months: 7.69 %
- 1 - 2 years: 0.0 %
- 2 - 5 years: 23.08 %
- 5 - 10 years: 0.0 %
- 10+ years: 0.0 %
What is the gender of people who have Ear buzzing when taking Hydramine? *
- female: 56.54 %
- male: 43.46 %
What is the age of people who have Ear buzzing when taking Hydramine? *
- 0-1: 0.0 %
- 2-9: 0.0 %
- 10-19: 0.0 %
- 20-29: 3.49 %
- 30-39: 7.42 %
- 40-49: 16.59 %
- 50-59: 27.95 %
- 60+: 44.54 %
What are other drugs people take besides Hydramine? *
- Acetaminophen: 123 people, 34.07%
- Tylenol: 81 people, 22.44%
- Prednisone: 80 people, 22.16%
- Actemra: 76 people, 21.05%
- Rituxan: 70 people, 19.39%
- Methylprednisolone: 64 people, 17.73%
- Epinephrine: 63 people, 17.45%
- Omeprazole: 55 people, 15.24%
- Sodium Chloride: 54 people, 14.96%
- Remicade: 54 people, 14.96%
What are other side effects people have besides Ear buzzing? *
- Headache (pain in head): 158 people, 43.77%
- Fatigue (feeling of tiredness): 140 people, 38.78%
- Pain: 138 people, 38.23%
- Nausea (feeling of having an urge to vomit): 123 people, 34.07%
- Joint Pain: 102 people, 28.25%
- Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 99 people, 27.42%
- High Blood Pressure: 94 people, 26.04%
- Drug Ineffective: 91 people, 25.21%
- Stress And Anxiety: 88 people, 24.38%
- Infusion Related Reaction: 84 people, 23.27%
What are the existing conditions these people have? *
- Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 131 people, 36.29%
- Immunodeficiency Common Variable: 44 people, 12.19%
- Pain: 41 people, 11.36%
- High Blood Pressure: 27 people, 7.48%
- Joint Pain: 18 people, 4.99%
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 3.32%
- Nausea And Vomiting: 10 people, 2.77%
- Depression: 10 people, 2.77%
- Endocrine Ophthalmopathy (increased water content of retroocular orbital tissues; associated with thyroid disease, usually hyperthyroidism): 10 people, 2.77%
- Nausea (feeling of having an urge to vomit): 10 people, 2.77%
* Approximation only. Some reports may have incomplete information.
Do you take Hydramine and have Ear buzzing?
- Check whether Ear buzzing is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, long term effects of, and alternative drugs to Hydramine:
- Hydramine (114,898 reports)
Ear buzzing treatments and more:
- Ear buzzing (58,539 reports)
How severe was Ear buzzing and when was it recovered:
Expand to all the drugs that have ingredients of diphenhydramine hydrochloride:
Sub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Common Hydramine side effects:
- Hydramine side effect: Headache (pain in head) (11,866 reports)
- Hydramine side effect: Nausea (feeling of having an urge to vomit) (10,359 reports)
- Hydramine side effect: Infusion related reaction (9,798 reports)
- Hydramine side effect: Drug ineffective (9,148 reports)
Browse all side effects of Hydramine:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon drugs associated with Ear buzzing:
- Aspirin side effect: Ear buzzing (2,601 reports)
- Cymbalta side effect: Ear buzzing (2,427 reports)
- Omeprazole side effect: Ear buzzing (1,980 reports)
- Prednisone side effect: Ear buzzing (1,929 reports)
- Gabapentin side effect: Ear buzzing (1,485 reports)
- Vitamin d side effect: Ear buzzing (1,427 reports)
- Simvastatin side effect: Ear buzzing (1,395 reports)
- Zide side effect: Ear buzzing (1,376 reports)
- Hydrochlorothiazide side effect: Ear buzzing (1,375 reports)
- Wellbutrin side effect: Ear buzzing (1,341 reports)
Browse all the drugs that are associated with Ear buzzing:
- Ear buzzing (2,439 drugs)
Common conditions associated with Ear buzzing:
- Depression: 3,635 reports
- Antidepressant therapy: 3,623 reports
- Hypertension aggravated: 2,663 reports
- Htn: 2,652 reports
- Arthritis - rheumatoid: 1,927 reports
- Anxiety aggravated: 1,913 reports
- Jitters: 1,912 reports
- Pain exacerbated: 1,795 reports
- Pain relief: 1,778 reports
- High blood cholesterol: 1,671 reports
Browse all the conditions that are associated with Ear buzzing:
- Ear buzzing (3,078 conditions)
Drugs similar to Hydramine and Ear buzzing :
- Ambien side effect: Ear buzzing
- Ambien cr side effect: Ear buzzing
- Amitriptyline hydrochloride side effect: Ear buzzing
- Ativan side effect: Ear buzzing
- Clonazepam side effect: Ear buzzing
- Clonidine side effect: Ear buzzing
- Desyrel side effect: Ear buzzing
- Doxepin hydrochloride side effect: Ear buzzing
- Doxylamine succinate side effect: Ear buzzing
- Hydroxyzine side effect: Ear buzzing
- Klonopin side effect: Ear buzzing
- Loraz side effect: Ear buzzing
- Lorazepam side effect: Ear buzzing
- Lunesta side effect: Ear buzzing
- Magnesium side effect: Ear buzzing
- Melatonin side effect: Ear buzzing
- Mirtazapine side effect: Ear buzzing
- Quetiapine fumarate side effect: Ear buzzing
- Remeron side effect: Ear buzzing
- Restoril side effect: Ear buzzing
- Seroquel side effect: Ear buzzing
- Temaz side effect: Ear buzzing
- Temazepam side effect: Ear buzzing
- Trazodone hydrochloride side effect: Ear buzzing
- Unisom side effect: Ear buzzing
- Xanax side effect: Ear buzzing
- Zolpidem side effect: Ear buzzing
- Zolpidem tartrate side effect: Ear buzzing
- Zopiclone side effect: Ear buzzing
How the study uses the data?
The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Hydramine) and Hydramine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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