Hydramine and Euphoric mood - a phase IV clinical study of FDA data

Summary:

Euphoric mood is reported as a side effect among people who take Hydramine (diphenhydramine hydrochloride), especially for people who are male, 40-49 old, have been taking the drug for < 1 month also take Acetaminophen, and have Crohn's disease.

The phase IV clinical study analyzes which people have Euphoric mood when taking Hydramine. It is created by eHealthMe based on reports of 113,450 people who have side effects when taking Hydramine from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

What is Euphoric mood?

Euphoric mood (excessively happy but may become angry or irritable) is found to be associated with 642 drugs and 860 conditions by eHealthMe. Check the latest studies of Euphoric mood.

On Jul, 17, 2026

113,450 people reported to have side effects when taking Hydramine.
Among them, 58 people (0.05%) have Euphoric mood.

Among these 58 people:

How long have people been on Hydramine when they have Euphoric mood? *

What is the gender of people who have Euphoric mood when taking Hydramine? *

female: 27.91 %
male: 72.09 %

What is the age of people who have Euphoric mood when taking Hydramine? *

What are other drugs people take besides Hydramine? *

Acetaminophen: 16 people, 27.59%
Inflectra: 10 people, 17.24%
Benadryl: 10 people, 17.24%
Tylenol: 10 people, 17.24%
Alprazolam: 8 people, 13.79%
Ergocalciferol: 7 people, 12.07%
Sulfasalazine: 7 people, 12.07%
Methylprednisolone Sodium Succinate: 6 people, 10.34%
Metformin: 6 people, 10.34%
Vitamin D3: 5 people, 8.62%

What are other side effects people have besides Euphoric mood? *

Pain: 31 people, 53.45%
Fatigue (feeling of tiredness): 24 people, 41.38%
Drowsiness: 23 people, 39.66%
Itching: 19 people, 32.76%
Headache (pain in head): 18 people, 31.03%
Infusion Related Reaction: 18 people, 31.03%
Infusion Site Extravasation (flow of (blood or lymph) from infusion site): 17 people, 29.31%
Tooth Abscess (pus formation in tooth): 15 people, 25.86%
Rash Erythematous (redness of the skin): 14 people, 24.14%
Rashes (redness): 14 people, 24.14%

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 16 people, 27.59%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 9 people, 15.52%
Depression: 8 people, 13.79%
Pain: 5 people, 8.62%
Diabetes: 4 people, 6.90%
Gastrointestinal Stromal Tumor: 4 people, 6.90%
Type 2 Diabetes: 3 people, 5.17%
High Blood Pressure: 3 people, 5.17%
Sleep Disorder: 3 people, 5.17%
Immunodeficiency Common Variable: 3 people, 5.17%

* Approximation only. Some reports may have incomplete information.

Do you take Hydramine and have Euphoric mood?

- Check whether Euphoric mood is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydramine:

Hydramine (114,900 reports)

Euphoric mood treatments and more:

Euphoric mood (12,696 reports)

Browse all side effects of Hydramine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Euphoric mood:

Euphoric mood (642 drugs)

Browse all the conditions that are associated with Euphoric mood:

Euphoric mood (860 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Hydramine) and Hydramine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.