Hydramine and Hyperthyroid - a phase IV clinical study of FDA data

Summary:

Hyperthyroid is reported as a side effect among people who take Hydramine (diphenhydramine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Acetaminophen, and have High blood pressure.

The phase IV clinical study analyzes which people have Hyperthyroid when taking Hydramine. It is created by eHealthMe based on reports of 113,450 people who have side effects when taking Hydramine from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,898 Hydramine users. Check the latest studies of Hydramine.

What is Hyperthyroid?

Hyperthyroid is found to be associated with 1,138 drugs and 1,409 conditions by eHealthMe. Check the latest studies of Hyperthyroid.

On Nov, 17, 2025

113,450 people reported to have side effects when taking Hydramine.
Among them, 58 people (0.05%) have Hyperthyroid.

Among these 58 people:

* Approximation only. Some reports may have incomplete information.

Do you take Hydramine and have Hyperthyroid?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydramine:

Hydramine (114,898 reports)

Hyperthyroid treatments and more:

Hyperthyroid (26,828 reports)

How severe was Hyperthyroid and when was it recovered:

Hyperthyroid in Hydramine

Expand to all the drugs that have ingredients of diphenhydramine hydrochloride:

Hyperthyroid and drugs with ingredients of diphenhydramine hydrochloride (225 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Hydramine side effects:

Hydramine side effect: Infusion related reaction (9,798 reports)

Browse all side effects of Hydramine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Hyperthyroid:

Browse all the drugs that are associated with Hyperthyroid:

Hyperthyroid (1,138 drugs)

Common conditions associated with Hyperthyroid:

Auricular fibrillation: 1,072 reports
Hypothyroid: 958 reports
Hypothyroidy: 957 reports
Hypertension aggravated: 904 reports
Hbp: 900 reports
Multiple sclerosis aggravated: 693 reports
Malignant melanoma: 553 reports
Pain: 444 reports
Osteoporosis: 434 reports
Alternative medicine - pain relief: 433 reports

Browse all the conditions that are associated with Hyperthyroid:

Hyperthyroid (1,409 conditions)

Drugs similar to Hydramine and Hyperthyroid :

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Hydramine) and Hydramine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.