Hydramine and Ischaemic stroke - a phase IV clinical study of FDA data

Summary:

Ischaemic stroke is reported as a side effect among people who take Hydramine (diphenhydramine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Ondansetron, and have Ulcerative colitis.

The phase IV clinical study analyzes which people have Ischaemic stroke when taking Hydramine. It is created by eHealthMe based on reports of 113,450 people who have side effects when taking Hydramine from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

What is Ischaemic stroke?

Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain) is found to be associated with 845 drugs and 1,095 conditions by eHealthMe. Check the latest studies of Ischaemic stroke.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

113,450 people reported to have side effects when taking Hydramine.
Among them, 41 people (0.04%) have Ischaemic stroke.

Among these 41 people:

How long have people been on Hydramine when they have Ischaemic stroke? *

What is the gender of people who have Ischaemic stroke when taking Hydramine? *

female: 82.86 %
male: 17.14 %

What is the age of people who have Ischaemic stroke when taking Hydramine? *

What are other drugs people take besides Hydramine? *

What are other side effects people have besides Ischaemic stroke? *

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 12 people, 29.27%
High Blood Pressure: 10 people, 24.39%
Diarrhea: 10 people, 24.39%
Balance Disorder: 9 people, 21.95%
Gait Disturbance: 9 people, 21.95%
Stress And Anxiety: 9 people, 21.95%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 8 people, 19.51%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 8 people, 19.51%
Hemiparesis (weakness on one side of the body): 8 people, 19.51%
Mobility Decreased (ability to move is reduced): 8 people, 19.51%

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 8 people, 19.51%
High Blood Pressure: 6 people, 14.63%
Nausea (feeling of having an urge to vomit): 5 people, 12.20%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 12.20%
Pain: 5 people, 12.20%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 5 people, 12.20%
Fever: 5 people, 12.20%
Leiomyosarcoma Metastatic (a very rare soft tissue sarcoma (cancer) that grows in muscle tissue spreading to other parts): 4 people, 9.76%
Dyslipidaemia (abnormal amount of lipids): 4 people, 9.76%
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble): 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

Do you take Hydramine and have Ischaemic stroke?

- Check whether Ischaemic stroke is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydramine:

Hydramine (114,900 reports)

Ischaemic stroke treatments and more:

Ischaemic stroke (25,786 reports)

Browse all side effects of Hydramine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ischaemic stroke:

Ischaemic stroke (845 drugs)

Browse all the conditions that are associated with Ischaemic stroke:

Ischaemic stroke (1,095 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Hydramine) and Hydramine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.