Hydramine and Mean cell volume increased - a phase IV clinical study of FDA data

Summary:

Mean cell volume increased is reported as a side effect among people who take Hydramine (diphenhydramine hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Acetaminophen, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Mean cell volume increased when taking Hydramine. It is created by eHealthMe based on reports of 113,450 people who have side effects when taking Hydramine from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

What is Mean cell volume increased?

Mean cell volume increased (more than normal average red blood cell volume) is found to be associated with 454 drugs and 495 conditions by eHealthMe. Check the latest studies of Mean cell volume increased.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

113,450 people reported to have side effects when taking Hydramine.
Among them, 62 people (0.05%) have Mean cell volume increased.

Could Hydramine cause Mean cell volume increased?

Among these 62 people:

How long have people been on Hydramine when they have Mean cell volume increased? *

What is the gender of people who have Mean cell volume increased when taking Hydramine? *

female: 43.48 %
male: 56.52 %

What is the age of people who have Mean cell volume increased when taking Hydramine? *

What are other drugs people take besides Hydramine? *

What are other side effects people have besides Mean cell volume increased? *

Mean Cell Haemoglobin Increased (more than normal haemoglobin per red blood cell in a sample of blood): 38 people, 61.29%
Red Blood Cell Count Decreased: 34 people, 54.84%
Thrombocytopenia (decrease of platelets in blood): 31 people, 50.00%
Lymphocyte Count Decreased: 30 people, 48.39%
Fatigue (feeling of tiredness): 29 people, 46.77%
Haemoglobin Decreased: 27 people, 43.55%
Haematocrit Decreased: 26 people, 41.94%
White Blood Cell Count Increased: 20 people, 32.26%
High Blood Pressure: 19 people, 30.65%
Neutrophil Count Increased (excess than normal number of neutrophil a type of blood cell): 18 people, 29.03%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 10 people, 16.13%
Brain Neoplasm Malignant (brain cancer tumour): 9 people, 14.52%
Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 6 people, 9.68%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 6 people, 9.68%
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans): 5 people, 8.06%
High Blood Pressure: 3 people, 4.84%
Hypersensitivity: 3 people, 4.84%
Birth Control: 3 people, 4.84%
Diarrhea: 3 people, 4.84%
Ovarian Cancer (cancer of ovary): 3 people, 4.84%

* Approximation only. Some reports may have incomplete information.

Do you take Hydramine and have Mean cell volume increased?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydramine:

Hydramine (114,900 reports)

Browse all side effects of Hydramine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mean cell volume increased:

Mean cell volume increased (454 drugs)

Browse all the conditions that are associated with Mean cell volume increased:

Mean cell volume increased (495 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Hydramine) and Hydramine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.