Hydramine and Systemic lupus erythematosus rash - a phase IV clinical study of FDA data

Summary:

Systemic lupus erythematosus rash is reported as a side effect among people who take Hydramine (diphenhydramine hydrochloride), especially for people who are female, 60+ old, also take Synthroid, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Systemic lupus erythematosus rash when taking Hydramine. It is created by eHealthMe based on reports of 113,450 people who have side effects when taking Hydramine from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

What is Systemic lupus erythematosus rash?

Systemic lupus erythematosus rash (an autoimmune disease, which means the body's immune system mistakenly attacks healthy tissue and causes the rashes) is found to be associated with 92 drugs and 233 conditions by eHealthMe. Check the latest studies of Systemic lupus erythematosus rash.

On Jul, 15, 2026

113,450 people reported to have side effects when taking Hydramine.
Among them, 43 people (0.04%) have Systemic lupus erythematosus rash.

Could Hydramine cause Systemic lupus erythematosus rash?

Among these 43 people:

What is the gender of people who have Systemic lupus erythematosus rash when taking Hydramine? *

female: 96.43 %
male: 3.57 %

What is the age of people who have Systemic lupus erythematosus rash when taking Hydramine? *

What are other drugs people take besides Hydramine? *

What are other side effects people have besides Systemic lupus erythematosus rash? *

Nasopharyngitis (inflammation of the nasopharynx): 36 people, 83.72%
Drug Ineffective: 33 people, 76.74%
Fatigue (feeling of tiredness): 33 people, 76.74%
Joint Pain: 33 people, 76.74%
Joint Swelling: 33 people, 76.74%
Dizziness: 32 people, 74.42%
Diarrhea: 30 people, 69.77%
Dyspnea (difficult or laboured breathing): 29 people, 67.44%
Dry Mouth: 29 people, 67.44%
Tooth Injury: 24 people, 55.81%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 33 people, 76.74%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 27 people, 62.79%
Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 23 people, 53.49%
Myositis (inflammation of the muscles): 23 people, 53.49%
Mixed Connective Tissue Disease (an autoimmune disease, in which the body's defence system attacks itself): 23 people, 53.49%
Vasculitis (inflammation of a blood vessel or blood vessels): 21 people, 48.84%
Primary Immunodeficiency Syndrome: 3 people, 6.98%
Immune System Disorder: 3 people, 6.98%
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 3 people, 6.98%
Immunodeficiency Common Variable: 1 person, 2.33%

* Approximation only. Some reports may have incomplete information.

Do you take Hydramine and have Systemic lupus erythematosus rash?

- Check whether Systemic lupus erythematosus rash is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydramine:

Hydramine (114,900 reports)

Browse all side effects of Hydramine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Systemic lupus erythematosus rash:

Systemic lupus erythematosus rash (92 drugs)

Browse all the conditions that are associated with Systemic lupus erythematosus rash:

Systemic lupus erythematosus rash (233 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Hydramine) and Hydramine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.