Hydrea and Mental status changes - a phase IV clinical study of FDA data

Summary:

Mental status changes is reported as a side effect among people who take Hydrea (hydroxyurea), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Compazine, and have Chronic myeloid leukaemia.

The phase IV clinical study analyzes which people have Mental status changes when taking Hydrea. It is created by eHealthMe based on reports of 8,922 people who have side effects when taking Hydrea from the FDA, and is updated regularly.

What is Hydrea?

Hydrea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 9,083 Hydrea users. Check the latest studies of Hydrea.

What is Mental status changes?

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation) is found to be associated with 1,496 drugs and 1,760 conditions by eHealthMe. Check the latest studies of Mental status changes.

On Aug, 01, 2026

8,922 people reported to have side effects when taking Hydrea.
Among them, 21 people (0.24%) have Mental status changes.

Could Hydrea cause Mental status changes?

Among these 21 people:

How long have people been on Hydrea when they have Mental status changes? *

What is the gender of people who have Mental status changes when taking Hydrea? *

female: 65 %
male: 35 %

What is the age of people who have Mental status changes when taking Hydrea? *

What are other drugs people take besides Hydrea? *

What are other side effects people have besides Mental status changes? *

Fatigue (feeling of tiredness): 9 people, 42.86%
Dehydration (dryness resulting from the removal of water): 8 people, 38.10%
Fall: 8 people, 38.10%
Weakness: 7 people, 33.33%
Urinary Tract Infection: 7 people, 33.33%
Nausea (feeling of having an urge to vomit): 7 people, 33.33%
Head Injury: 7 people, 33.33%
Depression: 7 people, 33.33%
Haematoma (collection of blood outside the blood vessels): 6 people, 28.57%
Pneumonia: 6 people, 28.57%

What are the existing conditions these people have? *

Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 6 people, 28.57%
Tumor Lysis Syndrome: 2 people, 9.52%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 2 people, 9.52%
Candidiasis (candidiasis or thrush is a fungal infection): 2 people, 9.52%
Depression: 2 people, 9.52%
Fluid Overload (too much fluid in the blood): 2 people, 9.52%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 9.52%
Indigestion: 2 people, 9.52%
Pain: 2 people, 9.52%
Stress And Anxiety: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Hydrea and have Mental status changes?

- Check whether Mental status changes is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydrea:

Hydrea (9,083 reports)

Browse all side effects of Hydrea:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mental status changes:

Mental status changes (1,496 drugs)

Browse all the conditions that are associated with Mental status changes:

Mental status changes (1,760 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydroxyurea (the active ingredients of Hydrea) and Hydrea (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.