Hydrochlorothiazide and Abnormal weight gain - a phase IV clinical study of FDA data

Summary:

Abnormal weight gain is reported as a side effect among people who take Hydrochlorothiazide (hydrochlorothiazide), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Prilosec, and have Multiple allergies.

The phase IV clinical study analyzes which people have Abnormal weight gain when taking Hydrochlorothiazide. It is created by eHealthMe based on reports of 177,544 people who have side effects when taking Hydrochlorothiazide from the FDA, and is updated regularly.

What is Hydrochlorothiazide?

Hydrochlorothiazide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 182,194 Hydrochlorothiazide users. Check the latest studies of Hydrochlorothiazide.

What is Abnormal weight gain?

Abnormal weight gain is found to be associated with 257 drugs and 710 conditions by eHealthMe. Check the latest studies of Abnormal weight gain.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

177,544 people reported to have side effects when taking Hydrochlorothiazide.
Among them, 21 people (0.01%) have Abnormal weight gain.

Could Hydrochlorothiazide cause Abnormal weight gain?

Among these 21 people:

How long have people been on Hydrochlorothiazide when they have Abnormal weight gain? *

What is the gender of people who have Abnormal weight gain when taking Hydrochlorothiazide? *

female: 76.19 %
male: 23.81 %

What is the age of people who have Abnormal weight gain when taking Hydrochlorothiazide? *

What are other drugs people take besides Hydrochlorothiazide? *

What are other side effects people have besides Abnormal weight gain? *

Dyspnea (difficult or laboured breathing): 4 people, 19.05%
Weakness: 4 people, 19.05%
Drug Ineffective: 4 people, 19.05%
Pain In Extremity: 4 people, 19.05%
Fatigue (feeling of tiredness): 3 people, 14.29%
Maternal Exposure During Pregnancy (use of substance during pregnancy): 3 people, 14.29%
Joint Swelling: 3 people, 14.29%
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 3 people, 14.29%
Head Injury: 3 people, 14.29%
Haptoglobin Decreased: 3 people, 14.29%

What are the existing conditions these people have? *

Primary Hyperaldosteronism (too much aldosterone is produced by the adrenal glands): 3 people, 14.29%
Birth Control: 3 people, 14.29%
Cushing's Syndrome (obesity, a rounded face, increased fat): 3 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 14.29%
Gestational Hypertension (elevated blood pressure during pregnancy): 3 people, 14.29%
High Blood Cholesterol: 3 people, 14.29%
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 3 people, 14.29%
Multiple Allergies (allergy to multiple agents): 3 people, 14.29%
Hypersensitivity: 2 people, 9.52%
Depression: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Hydrochlorothiazide and have Abnormal weight gain?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydrochlorothiazide:

Hydrochlorothiazide (182,194 reports)

Browse all side effects of Hydrochlorothiazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Abnormal weight gain:

Abnormal weight gain (257 drugs)

Browse all the conditions that are associated with Abnormal weight gain:

Abnormal weight gain (710 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Hydrochlorothiazide) and Hydrochlorothiazide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.