Hydrochlorothiazide and Cerebral atrophy - a phase IV clinical study of FDA data

Summary:

Cerebral atrophy is reported as a side effect among people who take Hydrochlorothiazide (hydrochlorothiazide), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Zometa, and have Depression.

The phase IV clinical study analyzes which people have Cerebral atrophy when taking Hydrochlorothiazide. It is created by eHealthMe based on reports of 177,544 people who have side effects when taking Hydrochlorothiazide from the FDA, and is updated regularly.

What is Hydrochlorothiazide?

Hydrochlorothiazide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 182,194 Hydrochlorothiazide users. Check the latest studies of Hydrochlorothiazide.

What is Cerebral atrophy?

Cerebral atrophy (decrement in size of brain) is found to be associated with 807 drugs and 856 conditions by eHealthMe. Check the latest studies of Cerebral atrophy.

On Jul, 04, 2026

177,544 people reported to have side effects when taking Hydrochlorothiazide.
Among them, 163 people (0.09%) have Cerebral atrophy.

Could Hydrochlorothiazide cause Cerebral atrophy?

Among these 163 people:

How long have people been on Hydrochlorothiazide when they have Cerebral atrophy? *

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What is the gender of people who have Cerebral atrophy when taking Hydrochlorothiazide? *

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What is the age of people who have Cerebral atrophy when taking Hydrochlorothiazide? *

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* Approximation only. Some reports may have incomplete information.

Do you take Hydrochlorothiazide and have Cerebral atrophy?

- Check whether Cerebral atrophy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydrochlorothiazide:

Hydrochlorothiazide (182,194 reports)

Cerebral atrophy treatments and more:

Cerebral atrophy (6,052 reports)

How severe was Cerebral atrophy and when was it recovered:

Cerebral atrophy in Hydrochlorothiazide

Expand to all the drugs that have ingredients of hydrochlorothiazide:

Cerebral atrophy and drugs with ingredients of hydrochlorothiazide

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hydrochlorothiazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cerebral atrophy:

Cerebral atrophy (807 drugs)

Browse all the conditions that are associated with Cerebral atrophy:

Cerebral atrophy (856 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Hydrochlorothiazide) and Hydrochlorothiazide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.