Hydrochlorothiazide and Chondropathy - a phase IV clinical study of FDA data

Summary:

Chondropathy is reported as a side effect among people who take Hydrochlorothiazide (hydrochlorothiazide), especially for people who are female, 60+ old, also take Valsartan, and have Essential tremor.

The phase IV clinical study analyzes which people have Chondropathy when taking Hydrochlorothiazide. It is created by eHealthMe based on reports of 177,544 people who have side effects when taking Hydrochlorothiazide from the FDA, and is updated regularly.

What is Hydrochlorothiazide?

Hydrochlorothiazide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 182,194 Hydrochlorothiazide users. Check the latest studies of Hydrochlorothiazide.

What is Chondropathy?

Chondropathy (disease of the cartilage) is found to be associated with 365 drugs and 434 conditions by eHealthMe. Check the latest studies of Chondropathy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

177,544 people reported to have side effects when taking Hydrochlorothiazide.
Among them, 96 people (0.05%) have Chondropathy.

Could Hydrochlorothiazide cause Chondropathy?

Among these 96 people:

What is the gender of people who have Chondropathy when taking Hydrochlorothiazide? *

female: 52.17 %
male: 47.83 %

What is the age of people who have Chondropathy when taking Hydrochlorothiazide? *

What are other drugs people take besides Hydrochlorothiazide? *

Amlodipine: 27 people, 28.12%
Valsartan: 27 people, 28.12%
Felodipine: 26 people, 27.08%
Torsemide: 26 people, 27.08%
Captopril: 26 people, 27.08%
Verapamil Hydrochloride: 24 people, 25.00%
Kerlone: 23 people, 23.96%
Humira: 18 people, 18.75%
Premarin: 9 people, 9.38%
Vitamin D3: 9 people, 9.38%

What are other side effects people have besides Chondropathy? *

Joint Pain: 57 people, 59.38%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 47 people, 48.96%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 36 people, 37.50%
Pain: 36 people, 37.50%
Back Pain: 35 people, 36.46%
Gait Disturbance: 35 people, 36.46%
Fatigue (feeling of tiredness): 33 people, 34.38%
Weakness: 33 people, 34.38%
Dizziness: 33 people, 34.38%
High Blood Cholesterol: 30 people, 31.25%

What are the existing conditions these people have? *

Essential Tremor: 27 people, 28.12%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 21 people, 21.88%
Abdominal Discomfort: 7 people, 7.29%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 7 people, 7.29%
Pain: 7 people, 7.29%
Intervertebral Disc Protrusion (spinal disc protrusion): 7 people, 7.29%
Thyroid Diseases: 6 people, 6.25%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 6 people, 6.25%
Psoriasis (immune-mediated disease that affects the skin): 6 people, 6.25%
Diabetes: 6 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Hydrochlorothiazide and have Chondropathy?

- Check whether Chondropathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydrochlorothiazide:

Hydrochlorothiazide (182,194 reports)

Chondropathy treatments and more:

Chondropathy (3,939 reports)

Browse all side effects of Hydrochlorothiazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Chondropathy:

Chondropathy (365 drugs)

Browse all the conditions that are associated with Chondropathy:

Chondropathy (434 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Hydrochlorothiazide) and Hydrochlorothiazide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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