Hydrochlorothiazide and Cluster headache - a phase IV clinical study of FDA data

Summary:

Cluster headache is reported as a side effect among people who take Hydrochlorothiazide (hydrochlorothiazide), especially for people who are male, 40-49 old, have been taking the drug for < 1 month also take Atorvastatin Calcium, and have Narcolepsy.

The phase IV clinical study analyzes which people have Cluster headache when taking Hydrochlorothiazide. It is created by eHealthMe based on reports of 177,544 people who have side effects when taking Hydrochlorothiazide from the FDA, and is updated regularly.

What is Hydrochlorothiazide?

Hydrochlorothiazide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 182,195 Hydrochlorothiazide users. Check the latest studies of Hydrochlorothiazide.

What is Cluster headache?

Cluster headache (one-sided head pain with tearing) is found to be associated with 237 drugs and 385 conditions by eHealthMe. Check the latest studies of Cluster headache.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

177,544 people reported to have side effects when taking Hydrochlorothiazide.
Among them, 28 people (0.02%) have Cluster headache.

Could Hydrochlorothiazide cause Cluster headache?

Among these 28 people:

How long have people been on Hydrochlorothiazide when they have Cluster headache? *

What is the gender of people who have Cluster headache when taking Hydrochlorothiazide? *

female: 50 %
male: 50 %

What is the age of people who have Cluster headache when taking Hydrochlorothiazide? *

What are other drugs people take besides Hydrochlorothiazide? *

Amlodipine Besylate: 9 people, 32.14%
Atorvastatin Calcium: 9 people, 32.14%
Triamterene And Hydrochlorothiazide: 8 people, 28.57%
Oxycodone And Acetaminophen: 8 people, 28.57%
Xyrem: 8 people, 28.57%
Klonopin: 8 people, 28.57%
Symbicort: 8 people, 28.57%
Melatonin: 8 people, 28.57%
Synthroid: 7 people, 25.00%
Lisinopril: 6 people, 21.43%

What are other side effects people have besides Cluster headache? *

Nightmares (unpleasant dreams): 14 people, 50.00%
Nausea (feeling of having an urge to vomit): 12 people, 42.86%
Back Pain: 10 people, 35.71%
Fatigue (feeling of tiredness): 10 people, 35.71%
Migraine (headache): 9 people, 32.14%
Pain: 9 people, 32.14%
Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 8 people, 28.57%
Night Sweats (sweating in night): 8 people, 28.57%
Kidney Stones: 8 people, 28.57%
Sleep Talking (talking during sleeping): 8 people, 28.57%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 28.57%
Pain: 6 people, 21.43%
Migraine (headache): 5 people, 17.86%
Immunodeficiency Common Variable: 5 people, 17.86%
Dyspnea (difficult or laboured breathing): 4 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 10.71%
Night Sweats (sweating in night): 3 people, 10.71%
Hypersensitivity: 3 people, 10.71%
Inflammation: 3 people, 10.71%
Depression: 3 people, 10.71%

* Approximation only. Some reports may have incomplete information.

Do you take Hydrochlorothiazide and have Cluster headache?

- Check whether Cluster headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydrochlorothiazide:

Hydrochlorothiazide (182,195 reports)

Browse all side effects of Hydrochlorothiazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cluster headache:

Cluster headache (237 drugs)

Browse all the conditions that are associated with Cluster headache:

Cluster headache (385 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Hydrochlorothiazide) and Hydrochlorothiazide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.