Hydrochlorothiazide and Paraplegia - a phase IV clinical study of FDA data

Summary:

Paraplegia is reported as a side effect among people who take Hydrochlorothiazide (hydrochlorothiazide), especially for people who are male, 60+ old, also take Insulin, and have Fibromyalgia.

The phase IV clinical study analyzes which people have Paraplegia when taking Hydrochlorothiazide. It is created by eHealthMe based on reports of 177,544 people who have side effects when taking Hydrochlorothiazide from the FDA, and is updated regularly.

What is Hydrochlorothiazide?

Hydrochlorothiazide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 182,194 Hydrochlorothiazide users. Check the latest studies of Hydrochlorothiazide.

What is Paraplegia?

Paraplegia (paralysis of the legs and lower body) is found to be associated with 436 drugs and 535 conditions by eHealthMe. Check the latest studies of Paraplegia.

On Jul, 27, 2026

177,544 people reported to have side effects when taking Hydrochlorothiazide.
Among them, 49 people (0.03%) have Paraplegia.

Could Hydrochlorothiazide cause Paraplegia?

Among these 49 people:

What is the gender of people who have Paraplegia when taking Hydrochlorothiazide? *

female: 45.65 %
male: 54.35 %

What is the age of people who have Paraplegia when taking Hydrochlorothiazide? *

What are other drugs people take besides Hydrochlorothiazide? *

What are other side effects people have besides Paraplegia? *

Extradural Haematoma (traumatic brain injury-collection of blood in the 'potential' space between the skull and the outer protective): 12 people, 24.49%
Spinal Cord Infarction (tissue damage of spinal cord due to lack of blood supply): 10 people, 20.41%
Back Pain: 9 people, 18.37%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 9 people, 18.37%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 9 people, 18.37%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 8 people, 16.33%
Mobility Decreased (ability to move is reduced): 8 people, 16.33%
Coordination Abnormal (abnormal movement): 8 people, 16.33%
Guillain-Barre Syndrome (the body's immune system attacks its peripheral nervous system): 8 people, 16.33%
Dizziness: 7 people, 14.29%

What are the existing conditions these people have? *

Fibromyalgia (a long-term condition which causes pain all over the body): 10 people, 20.41%
Herniated Nucleus Pulposus (Slipped Disk): 7 people, 14.29%
Pain: 6 people, 12.24%
Breakthrough Pain: 5 people, 10.20%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 8.16%
Acute Coronary Syndrome (acute chest pain and other symptoms that happen because the heart does not get blood): 4 people, 8.16%
Sedation: 4 people, 8.16%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 6.12%
Type 1 Diabetes: 3 people, 6.12%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

Do you take Hydrochlorothiazide and have Paraplegia?

- Check whether Paraplegia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydrochlorothiazide:

Hydrochlorothiazide (182,194 reports)

Paraplegia treatments and more:

Paraplegia (3,983 reports)

Browse all side effects of Hydrochlorothiazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Paraplegia:

Paraplegia (436 drugs)

Browse all the conditions that are associated with Paraplegia:

Paraplegia (535 conditions)

Related publications that referenced our studies

Lee, Y. J., & Park, K. , "Secondary Raynaud’s Phenomenon and Skin Necrosis of Toes in the Paraplegic Patient with Hypertension", Drug safety-case reports, 2018 Jan .
Lee, Y. J., & Park, K. , "Secondary Raynaud’s Phenomenon and Skin Necrosis of Toes in the Paraplegic Patient with Hypertension", Drug safety-case reports, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Hydrochlorothiazide) and Hydrochlorothiazide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.