Hydrochlorothiazide and Spleen disorder - a phase IV clinical study of FDA data

Summary:

Spleen disorder is reported as a side effect among people who take Hydrochlorothiazide (hydrochlorothiazide), especially for people who are male, 60+ old, also take Luvox, and have Relapsing-remitting multiple sclerosis.

The phase IV clinical study analyzes which people have Spleen disorder when taking Hydrochlorothiazide. It is created by eHealthMe based on reports of 177,544 people who have side effects when taking Hydrochlorothiazide from the FDA, and is updated regularly.

What is Hydrochlorothiazide?

Hydrochlorothiazide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 182,194 Hydrochlorothiazide users. Check the latest studies of Hydrochlorothiazide.

What is Spleen disorder?

Spleen disorder (disease of spleen) is found to be associated with 383 drugs and 409 conditions by eHealthMe. Check the latest studies of Spleen disorder.

On Jul, 10, 2026

177,544 people reported to have side effects when taking Hydrochlorothiazide.
Among them, 32 people (0.02%) have Spleen disorder.

Could Hydrochlorothiazide cause Spleen disorder?

Among these 32 people:

What is the gender of people who have Spleen disorder when taking Hydrochlorothiazide? *

female: 37.04 %
male: 62.96 %

What is the age of people who have Spleen disorder when taking Hydrochlorothiazide? *

What are other drugs people take besides Hydrochlorothiazide? *

What are other side effects people have besides Spleen disorder? *

Fatigue (feeling of tiredness): 16 people, 50.00%
Depression: 13 people, 40.62%
Hair Loss: 11 people, 34.38%
White Blood Cell Count Decreased: 10 people, 31.25%
Renal Cyst (kidney cyst): 10 people, 31.25%
Lymphopenia (an abnormally low level of lymphocytes in the blood): 10 people, 31.25%
Haemangioma Of Spleen (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in spleen): 10 people, 31.25%
Neutrophil Count Decreased (less than normal number of neutrophil a type of blood cell): 10 people, 31.25%
Pain In Extremity: 5 people, 15.62%
Abdominal Pain: 5 people, 15.62%

What are the existing conditions these people have? *

Vitamin B12 Deficiency: 10 people, 31.25%
Tinnitus (a ringing in the ears): 10 people, 31.25%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 10 people, 31.25%
Depression: 7 people, 21.88%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 6.25%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 2 people, 6.25%
Primary Myelofibrosis (primary disorder of the bone marrow): 2 people, 6.25%
Pancreatic Neuroendocrine Tumor: 2 people, 6.25%
Pain: 2 people, 6.25%
Constipation: 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Hydrochlorothiazide and have Spleen disorder?

- Check whether Spleen disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydrochlorothiazide:

Hydrochlorothiazide (182,194 reports)

Spleen disorder treatments and more:

Spleen disorder (2,370 reports)

Browse all side effects of Hydrochlorothiazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Spleen disorder:

Spleen disorder (383 drugs)

Browse all the conditions that are associated with Spleen disorder:

Spleen disorder (409 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Hydrochlorothiazide) and Hydrochlorothiazide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.