Hydrocodone bitartrate and acetaminophen and Xerophthalmia - a phase IV clinical study of FDA data

Summary:

Xerophthalmia is reported as a side effect among people who take Hydrocodone bitartrate and acetaminophen (acetaminophen; hydrocodone bitartrate), especially for people who are female, 50-59 old, also take Loratadine, and have Bone cancer metastatic.

The phase IV clinical study analyzes which people have Xerophthalmia when taking Hydrocodone bitartrate and acetaminophen. It is created by eHealthMe based on reports of 65,271 people who have side effects when taking Hydrocodone bitartrate and acetaminophen from the FDA, and is updated regularly.

What is Hydrocodone bitartrate and acetaminophen?

Hydrocodone bitartrate and acetaminophen has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 67,662 Hydrocodone bitartrate and acetaminophen users. Check the latest studies of Hydrocodone bitartrate and acetaminophen.

What is Xerophthalmia?

Xerophthalmia (eye fails to produce tears) is found to be associated with 372 drugs and 697 conditions by eHealthMe. Check the latest studies of Xerophthalmia.

On Apr, 04, 2026

65,271 people reported to have side effects when taking Hydrocodone bitartrate and acetaminophen.
Among them, 11 people (0.02%) have Xerophthalmia.

Could Hydrocodone bitartrate and acetaminophen cause Xerophthalmia?

Among these 11 people:

What is the gender of people who have Xerophthalmia when taking Hydrocodone bitartrate and acetaminophen? *

female: 81.82 %
male: 18.18 %

What is the age of people who have Xerophthalmia when taking Hydrocodone bitartrate and acetaminophen? *

What are other drugs people take besides Hydrocodone bitartrate and acetaminophen? *

What are other side effects people have besides Xerophthalmia? *

Bone Disorder: 10 people, 90.91%
Cervical Spine Flattening: 9 people, 81.82%
Device Failure: 9 people, 81.82%
Depression: 9 people, 81.82%
Dry Mouth: 9 people, 81.82%
Lung Disorder (lung disease): 9 people, 81.82%
Gums - Swollen: 9 people, 81.82%
Nausea (feeling of having an urge to vomit): 9 people, 81.82%
Neck Pain: 9 people, 81.82%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 9 people, 81.82%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 9 people, 81.82%
Breast Cancer: 9 people, 81.82%
Bone Cancer Metastatic: 9 people, 81.82%
Osteomyelitis (infection of bone): 4 people, 36.36%

* Approximation only. Some reports may have incomplete information.

Do you take Hydrocodone bitartrate and acetaminophen and have Xerophthalmia?

- Check whether Xerophthalmia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydrocodone bitartrate and acetaminophen:

Hydrocodone bitartrate and acetaminophen (67,662 reports)

Xerophthalmia treatments and more:

Xerophthalmia (1,611 reports)

How severe was Xerophthalmia and when was it recovered:

Xerophthalmia in Hydrocodone bitartrate and acetaminophen

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Xerophthalmia and drugs with ingredients of acetaminophen; hydrocodone bitartrate (25 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hydrocodone bitartrate and acetaminophen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Xerophthalmia:

Xerophthalmia (372 drugs)

Browse all the conditions that are associated with Xerophthalmia:

Xerophthalmia (697 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Hydrocodone bitartrate and acetaminophen) and Hydrocodone bitartrate and acetaminophen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.