Hydrocodone and Hyperglycemia - a phase IV clinical study of FDA data

Summary:

Hyperglycemia is reported as a side effect among people who take Hydrocodone (hydrocodone bitartrate; ibuprofen), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Lorazepam, and have Metastatic gastric cancer.

The phase IV clinical study analyzes which people have Hyperglycemia when taking Hydrocodone. It is created by eHealthMe based on reports of 13,053 people who have side effects when taking Hydrocodone from the FDA, and is updated regularly.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

What is Hyperglycemia?

Hyperglycemia (high blood sugar) is found to be associated with 1,658 drugs and 2,501 conditions by eHealthMe. Check the latest studies of Hyperglycemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

13,053 people reported to have side effects when taking Hydrocodone.
Among them, 29 people (0.22%) have Hyperglycemia.

Among these 29 people:

How long have people been on Hydrocodone when they have Hyperglycemia? *

What is the gender of people who have Hyperglycemia when taking Hydrocodone? *

female: 35.71 %
male: 64.29 %

What is the age of people who have Hyperglycemia when taking Hydrocodone? *

What are other drugs people take besides Hydrocodone? *

What are other side effects people have besides Hyperglycemia? *

Acute Kidney Failure: 10 people, 34.48%
Weakness: 9 people, 31.03%
Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 8 people, 27.59%
Nausea (feeling of having an urge to vomit): 7 people, 24.14%
Rashes (redness): 6 people, 20.69%
Hyperbilirubinaemia (excess of bilirubin in the blood): 6 people, 20.69%
Fatigue (feeling of tiredness): 6 people, 20.69%
Lobar Pneumonia (a form of pneumonia that affects a large and continuous area of the lobe of a lung): 5 people, 17.24%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 5 people, 17.24%
High Blood Pressure: 5 people, 17.24%

What are the existing conditions these people have? *

Metastatic Gastric Cancer (cancer types can spread to the stomach from other place): 8 people, 27.59%
Pain: 4 people, 13.79%
Nausea And Vomiting: 4 people, 13.79%
Nausea (feeling of having an urge to vomit): 4 people, 13.79%
Bipolar Disorder (mood disorder): 3 people, 10.34%
Waldenstrom's Macroglobulinaemia (cancer affects small lymphocytes (white blood cells)): 1 person, 3.45%
Gastric Disorder (disease of stomach): 1 person, 3.45%
Back Pain: 1 person, 3.45%
Bone Pain: 1 person, 3.45%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 3.45%

* Approximation only. Some reports may have incomplete information.

Do you take Hydrocodone and have Hyperglycemia?

- Check whether Hyperglycemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydrocodone:

Hydrocodone (13,115 reports)

Hyperglycemia treatments and more:

Hyperglycemia (48,691 reports)

How severe was Hyperglycemia and when was it recovered:

Hyperglycemia in Hydrocodone

Expand to all the drugs that have ingredients of hydrocodone bitartrate; ibuprofen:

Hyperglycemia and drugs with ingredients of hydrocodone bitartrate; ibuprofen (41 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hydrocodone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperglycemia:

Hyperglycemia (1,658 drugs)

Browse all the conditions that are associated with Hyperglycemia:

Hyperglycemia (2,501 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrocodone bitartrate; ibuprofen (the active ingredients of Hydrocodone) and Hydrocodone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.