Hydrocodone and Kidney stones - a phase IV clinical study of FDA data

Summary:

Kidney stones is reported as a side effect among people who take Hydrocodone (hydrocodone bitartrate; ibuprofen), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lyrica, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Kidney stones when taking Hydrocodone. It is created by eHealthMe based on reports of 13,053 people who have side effects when taking Hydrocodone from the FDA, and is updated regularly.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

What is Kidney stones?

Kidney stones is found to be associated with 1,837 drugs and 2,125 conditions by eHealthMe. Check the latest studies of Kidney stones.

On Jul, 14, 2026

13,053 people reported to have side effects when taking Hydrocodone.
Among them, 79 people (0.61%) have Kidney stones.

Among these 79 people:

How long have people been on Hydrocodone when they have Kidney stones? *

What is the gender of people who have Kidney stones when taking Hydrocodone? *

female: 64.29 %
male: 35.71 %

What is the age of people who have Kidney stones when taking Hydrocodone? *

What are other drugs people take besides Hydrocodone? *

What are other side effects people have besides Kidney stones? *

Pain: 30 people, 37.97%
Fatigue (feeling of tiredness): 30 people, 37.97%
Stress And Anxiety: 24 people, 30.38%
Urinary Tract Infection: 19 people, 24.05%
Back Pain: 17 people, 21.52%
Fall: 16 people, 20.25%
Weakness: 14 people, 17.72%
Head Injury: 13 people, 16.46%
Anhedonia (inability to experience pleasure from activities usually found enjoyable): 13 people, 16.46%
Nausea (feeling of having an urge to vomit): 13 people, 16.46%

What are the existing conditions these people have? *

Hiv Infection: 12 people, 15.19%
Immunodeficiency Common Variable: 12 people, 15.19%
Pain: 10 people, 12.66%
High Blood Pressure: 9 people, 11.39%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 10.13%
Depression: 6 people, 7.59%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 6.33%
Primary Progressive Multiple Sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 5 people, 6.33%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 5 people, 6.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 6.33%

* Approximation only. Some reports may have incomplete information.

Do you take Hydrocodone and have Kidney stones?

- Check whether Kidney stones is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydrocodone:

Hydrocodone (13,115 reports)

Kidney stones treatments and more:

Kidney stones (59,728 reports)

How severe was Kidney stones and when was it recovered:

Kidney stones in Hydrocodone

Expand to all the drugs that have ingredients of hydrocodone bitartrate; ibuprofen:

Kidney stones and drugs with ingredients of hydrocodone bitartrate; ibuprofen (121 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hydrocodone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Kidney stones:

Kidney stones (1,837 drugs)

Browse all the conditions that are associated with Kidney stones:

Kidney stones (2,125 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrocodone bitartrate; ibuprofen (the active ingredients of Hydrocodone) and Hydrocodone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.