Hydrocodone and Psychomotor hyperactivity - a phase IV clinical study of FDA data

Summary:

Psychomotor hyperactivity is reported as a side effect among people who take Hydrocodone (hydrocodone bitartrate; ibuprofen), especially for people who are female, 60+ old, also take Oxycodone, and have Pain.

The phase IV clinical study analyzes which people have Psychomotor hyperactivity when taking Hydrocodone. It is created by eHealthMe based on reports of 13,053 people who have side effects when taking Hydrocodone from the FDA, and is updated regularly.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

What is Psychomotor hyperactivity?

Psychomotor hyperactivity (feelings of extreme restlessness) is found to be associated with 886 drugs and 1,101 conditions by eHealthMe. Check the latest studies of Psychomotor hyperactivity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

13,053 people reported to have side effects when taking Hydrocodone.
Among them, 11 people (0.08%) have Psychomotor hyperactivity.

Could Hydrocodone cause Psychomotor hyperactivity?

Among these 11 people:

What is the gender of people who have Psychomotor hyperactivity when taking Hydrocodone? *

female: 54.55 %
male: 45.45 %

What is the age of people who have Psychomotor hyperactivity when taking Hydrocodone? *

What are other drugs people take besides Hydrocodone? *

Neurontin: 3 people, 27.27%
Oxycodone: 3 people, 27.27%
Xyrem: 2 people, 18.18%
Seroquel: 2 people, 18.18%
Oxycontin: 2 people, 18.18%
Fluticasone Propionate: 2 people, 18.18%
Enalapril Maleate: 2 people, 18.18%
Effexor: 2 people, 18.18%
Ritalin: 2 people, 18.18%
Temazepam: 2 people, 18.18%

What are other side effects people have besides Psychomotor hyperactivity? *

Pain: 4 people, 36.36%
Insomnia (sleeplessness): 4 people, 36.36%
Stress And Anxiety: 3 people, 27.27%
Intervertebral Disc Protrusion (spinal disc protrusion): 2 people, 18.18%
Rhinorrhea (watery mucus discharge from the nose): 2 people, 18.18%
Drug Dependence: 2 people, 18.18%
Drug Ineffective: 2 people, 18.18%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 2 people, 18.18%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 18.18%
Mania (a state of abnormally elevated or irritable mood): 2 people, 18.18%

What are the existing conditions these people have? *

Pain: 5 people, 45.45%
Depression: 3 people, 27.27%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 18.18%
Drowsiness: 2 people, 18.18%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 18.18%
Stress And Anxiety: 1 person, 9.09%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 9.09%
Intervertebral Disc Degeneration (spinal disc degeneration): 1 person, 9.09%
Ill-Defined Disorder: 1 person, 9.09%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Hydrocodone and have Psychomotor hyperactivity?

- Check whether Psychomotor hyperactivity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydrocodone:

Hydrocodone (13,115 reports)

Psychomotor hyperactivity treatments and more:

Psychomotor hyperactivity (20,459 reports)

How severe was Psychomotor hyperactivity and when was it recovered:

Psychomotor hyperactivity in Hydrocodone

Expand to all the drugs that have ingredients of hydrocodone bitartrate; ibuprofen:

Psychomotor hyperactivity and drugs with ingredients of hydrocodone bitartrate; ibuprofen (17 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hydrocodone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Psychomotor hyperactivity:

Psychomotor hyperactivity (886 drugs)

Browse all the conditions that are associated with Psychomotor hyperactivity:

Psychomotor hyperactivity (1,101 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrocodone bitartrate; ibuprofen (the active ingredients of Hydrocodone) and Hydrocodone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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