Hydrocodone and Sciatica - a phase IV clinical study of FDA data

Summary:

Sciatica is reported as a side effect among people who take Hydrocodone (hydrocodone bitartrate; ibuprofen), especially for people who are female, 60+ old, also take Gabapentin, and have Primary immunodeficiency syndrome.

The phase IV clinical study analyzes which people have Sciatica when taking Hydrocodone. It is created by eHealthMe based on reports of 13,053 people who have side effects when taking Hydrocodone from the FDA, and is updated regularly.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

What is Sciatica?

Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve) is found to be associated with 1,143 drugs and 1,433 conditions by eHealthMe. Check the latest studies of Sciatica.

On Jun, 16, 2026

13,053 people reported to have side effects when taking Hydrocodone.
Among them, 34 people (0.26%) have Sciatica.

Among these 34 people:

What is the gender of people who have Sciatica when taking Hydrocodone? *

female: 72.73 %
male: 27.27 %

What is the age of people who have Sciatica when taking Hydrocodone? *

What are other drugs people take besides Hydrocodone? *

What are other side effects people have besides Sciatica? *

Weakness: 15 people, 44.12%
Nausea (feeling of having an urge to vomit): 14 people, 41.18%
Pain: 13 people, 38.24%
Fall: 13 people, 38.24%
Headache (pain in head): 11 people, 32.35%
Joint Pain: 10 people, 29.41%
Gait Disturbance: 10 people, 29.41%
Chest Pain: 9 people, 26.47%
Drug Ineffective: 9 people, 26.47%
Pain In Extremity: 8 people, 23.53%

What are the existing conditions these people have? *

Hepatitis C: 5 people, 14.71%
Primary Immunodeficiency Syndrome: 5 people, 14.71%
Immunodeficiency Common Variable: 4 people, 11.76%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 8.82%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 8.82%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 8.82%
Diabetes: 3 people, 8.82%
Pain: 3 people, 8.82%
High Blood Cholesterol: 2 people, 5.88%
Nerve Injury: 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Hydrocodone and have Sciatica?

- Check whether Sciatica is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydrocodone:

Hydrocodone (13,115 reports)

Sciatica treatments and more:

Sciatica (28,509 reports)

How severe was Sciatica and when was it recovered:

Sciatica in Hydrocodone

Expand to all the drugs that have ingredients of hydrocodone bitartrate; ibuprofen:

Sciatica and drugs with ingredients of hydrocodone bitartrate; ibuprofen

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hydrocodone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sciatica:

Sciatica (1,143 drugs)

Browse all the conditions that are associated with Sciatica:

Sciatica (1,433 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrocodone bitartrate; ibuprofen (the active ingredients of Hydrocodone) and Hydrocodone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.