Hydroxychloroquine sulfate and Peripheral coldness - a phase IV clinical study of FDA data

Summary:

Peripheral coldness is reported as a side effect among people who take Hydroxychloroquine sulfate (hydroxychloroquine sulfate), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Prednisone, and have Headache.

The phase IV clinical study analyzes which people have Peripheral coldness when taking Hydroxychloroquine sulfate. It is created by eHealthMe based on reports of 50,935 people who have side effects when taking Hydroxychloroquine sulfate from the FDA, and is updated regularly.

What is Hydroxychloroquine sulfate?

Hydroxychloroquine sulfate has active ingredients of hydroxychloroquine sulfate. It is often used in rheumatoid arthritis. eHealthMe is studying from 52,084 Hydroxychloroquine sulfate users. Check the latest studies of Hydroxychloroquine sulfate.

What is Peripheral coldness?

Peripheral coldness is found to be associated with 1,081 drugs and 1,154 conditions by eHealthMe. Check the latest studies of Peripheral coldness.

On Aug, 05, 2026

50,935 people reported to have side effects when taking Hydroxychloroquine sulfate.
Among them, 42 people (0.08%) have Peripheral coldness.

Could Hydroxychloroquine sulfate cause Peripheral coldness?

Among these 42 people:

How long have people been on Hydroxychloroquine sulfate when they have Peripheral coldness? *

What is the gender of people who have Peripheral coldness when taking Hydroxychloroquine sulfate? *

female: 88.89 %
male: 11.11 %

What is the age of people who have Peripheral coldness when taking Hydroxychloroquine sulfate? *

What are other drugs people take besides Hydroxychloroquine sulfate? *

Acetaminophen: 16 people, 38.10%
Prednisone: 16 people, 38.10%
Vagifem: 14 people, 33.33%
Gravol: 14 people, 33.33%
Magnesium: 14 people, 33.33%
Glucosamine: 14 people, 33.33%
Methotrexate: 14 people, 33.33%
Premarin: 14 people, 33.33%
Vitamin D3: 14 people, 33.33%
Lactobacillus Acidophilus: 14 people, 33.33%

What are other side effects people have besides Peripheral coldness? *

Pain: 23 people, 54.76%
Joint Pain: 22 people, 52.38%
Cough: 22 people, 52.38%
Malaise (a feeling of general discomfort or uneasiness): 20 people, 47.62%
High Blood Pressure: 19 people, 45.24%
Drug Ineffective: 18 people, 42.86%
Osteoporosis (bones weak and more likely to break): 17 people, 40.48%
Abdominal Pain Upper: 17 people, 40.48%
Nausea (feeling of having an urge to vomit): 17 people, 40.48%
Burning Sensation: 17 people, 40.48%

What are the existing conditions these people have? *

Headache (pain in head): 3 people, 7.14%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 4.76%
Pain: 2 people, 4.76%
High Blood Pressure: 2 people, 4.76%
Raynaud's Phenomenon (discoloration of the fingers, toes, and occasionally other areas): 1 person, 2.38%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 2.38%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 1 person, 2.38%
Nasal Polyps (masses that develop in the lining of the nose): 1 person, 2.38%
Migraine (headache): 1 person, 2.38%
Cutaneous Lupus Erythematosus (own immune system attacks various cells causing a wide variety of signs and symptoms): 1 person, 2.38%

* Approximation only. Some reports may have incomplete information.

Do you take Hydroxychloroquine sulfate and have Peripheral coldness?

- Check whether Peripheral coldness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydroxychloroquine sulfate:

Hydroxychloroquine sulfate (52,084 reports)

Browse all side effects of Hydroxychloroquine sulfate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Peripheral coldness:

Peripheral coldness (1,081 drugs)

Browse all the conditions that are associated with Peripheral coldness:

Peripheral coldness (1,154 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydroxychloroquine sulfate (the active ingredients of Hydroxychloroquine sulfate) and Hydroxychloroquine sulfate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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