Hydroxyurea and Sciatica - a phase IV clinical study of FDA data

Summary:

Sciatica is reported as a side effect among people who take Hydroxyurea (hydroxyurea), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Vitamin D3, and have Narcolepsy.

The phase IV clinical study analyzes which people have Sciatica when taking Hydroxyurea. It is created by eHealthMe based on reports of 16,937 people who have side effects when taking Hydroxyurea from the FDA, and is updated regularly.

What is Hydroxyurea?

Hydroxyurea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 17,238 Hydroxyurea users. Check the latest studies of Hydroxyurea.

What is Sciatica?

Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve) is found to be associated with 1,144 drugs and 1,428 conditions by eHealthMe. Check the latest studies of Sciatica.

On Apr, 14, 2026

16,937 people reported to have side effects when taking Hydroxyurea.
Among them, 19 people (0.11%) have Sciatica.

Among these 19 people:

How long have people been on Hydroxyurea when they have Sciatica? *

What is the gender of people who have Sciatica when taking Hydroxyurea? *

female: 100 %
male: 0.0 %

What is the age of people who have Sciatica when taking Hydroxyurea? *

What are other drugs people take besides Hydroxyurea? *

Jakafi: 9 people, 47.37%
Vitamin D3: 9 people, 47.37%
Premarin: 7 people, 36.84%
Xyrem: 6 people, 31.58%
Valsartan And Hydrochlorothiazide: 6 people, 31.58%
Aspirin: 6 people, 31.58%
Crestor: 6 people, 31.58%
Neulasta: 6 people, 31.58%
Percocet: 6 people, 31.58%
Abilify: 6 people, 31.58%

What are other side effects people have besides Sciatica? *

Nausea (feeling of having an urge to vomit): 10 people, 52.63%
High Blood Pressure: 9 people, 47.37%
Diarrhea: 8 people, 42.11%
Dyspnea (difficult or laboured breathing): 7 people, 36.84%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 7 people, 36.84%
Fatigue (feeling of tiredness): 6 people, 31.58%
Hypotension (abnormally low blood pressure): 6 people, 31.58%
Breast Cancer: 6 people, 31.58%
Dehydration (dryness resulting from the removal of water): 6 people, 31.58%
Sleep Apnea Syndrome: 6 people, 31.58%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 31.58%
Primary Myelofibrosis (primary disorder of the bone marrow): 4 people, 21.05%
Polycythaemia (proportion of blood volume that is occupied by red blood cells increases): 4 people, 21.05%
White Blood Cell Count Increased: 1 person, 5.26%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 1 person, 5.26%
Multiple Myeloma (cancer of the plasma cells): 1 person, 5.26%
Anaemia (lack of blood): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Hydroxyurea and have Sciatica?

- Check whether Sciatica is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydroxyurea:

Hydroxyurea (17,238 reports)

Sciatica treatments and more:

Sciatica (28,509 reports)

Browse all side effects of Hydroxyurea:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sciatica:

Sciatica (1,144 drugs)

Browse all the conditions that are associated with Sciatica:

Sciatica (1,428 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydroxyurea (the active ingredients of Hydroxyurea) and Hydroxyurea (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.