Hydroxyzine and Circulatory collapse - a phase IV clinical study of FDA data

Summary:

Circulatory collapse is reported as a side effect among people who take Hydroxyzine (hydroxyzine hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Acetaminophen, and have Sedation.

The phase IV clinical study analyzes which people have Circulatory collapse when taking Hydroxyzine. It is created by eHealthMe based on reports of 51,890 people who have side effects when taking Hydroxyzine from the FDA, and is updated regularly.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,070 Hydroxyzine users. Check the latest studies of Hydroxyzine.

What is Circulatory collapse?

Circulatory collapse is found to be associated with 1,122 drugs and 1,403 conditions by eHealthMe. Check the latest studies of Circulatory collapse.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

51,890 people reported to have side effects when taking Hydroxyzine.
Among them, 43 people (0.08%) have Circulatory collapse.

Could Hydroxyzine cause Circulatory collapse?

Among these 43 people:

How long have people been on Hydroxyzine when they have Circulatory collapse? *

What is the gender of people who have Circulatory collapse when taking Hydroxyzine? *

female: 61.11 %
male: 38.89 %

What is the age of people who have Circulatory collapse when taking Hydroxyzine? *

What are other drugs people take besides Hydroxyzine? *

Acetaminophen: 17 people, 39.53%
Codeine: 16 people, 37.21%
Midazolam: 14 people, 32.56%
Meloxicam: 9 people, 20.93%
Caffeine: 8 people, 18.60%
Piperacillin And Tazobactam: 8 people, 18.60%
Theobromine: 8 people, 18.60%
Alcohol: 8 people, 18.60%
Metoclopramide: 8 people, 18.60%
Voriconazole: 7 people, 16.28%

What are other side effects people have besides Circulatory collapse? *

Dyspnea (difficult or laboured breathing): 24 people, 55.81%
Fever: 15 people, 34.88%
Pneumonia Fungal: 15 people, 34.88%
Drug Ineffective: 15 people, 34.88%
High Blood Pressure: 15 people, 34.88%
Mydriasis (a dilation of the pupil): 15 people, 34.88%
Tremor (trembling or shaking movements in one or more parts of your body): 15 people, 34.88%
Delirium (wild excitement): 15 people, 34.88%
Joint Pain: 15 people, 34.88%
Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 15 people, 34.88%

What are the existing conditions these people have? *

Sedation: 16 people, 37.21%
Asthma: 14 people, 32.56%
Sinus Tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 14 people, 32.56%
Pain: 14 people, 32.56%
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles): 14 people, 32.56%
Pneumonia: 13 people, 30.23%
Fever: 13 people, 30.23%
Psychiatric Symptom: 11 people, 25.58%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 9 people, 20.93%
Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 4 people, 9.30%

* Approximation only. Some reports may have incomplete information.

Do you take Hydroxyzine and have Circulatory collapse?

- Check whether Circulatory collapse is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydroxyzine:

Hydroxyzine (54,070 reports)

Browse all side effects of Hydroxyzine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Circulatory collapse:

Circulatory collapse (1,122 drugs)

Browse all the conditions that are associated with Circulatory collapse:

Circulatory collapse (1,403 conditions)

Related publications that referenced our studies

Ate? ?, Arikan MF, Kaplan M, Altay M, "Hydroxyzine induced pancytopenia and petechial rashes: a rare complication", Journal Of Contemporary Medicine, 2017 Jan .
Ate? ?, Arikan MF, Kaplan M, Altay M, "Hydroxyzine induced pancytopenia and petechial rashes: a rare complication", Journal Of Contemporary Medicine, 2017 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on hydroxyzine hydrochloride (the active ingredients of Hydroxyzine) and Hydroxyzine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.