Hydroxyzine and Peripheral ischaemia - a phase IV clinical study of FDA data

Summary:

Peripheral ischaemia is reported as a side effect among people who take Hydroxyzine (hydroxyzine hydrochloride), especially for people who are female, 60+ old, also take Ditropan Xl, and have Migraine.

The phase IV clinical study analyzes which people have Peripheral ischaemia when taking Hydroxyzine. It is created by eHealthMe based on reports of 51,890 people who have side effects when taking Hydroxyzine from the FDA, and is updated regularly.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,069 Hydroxyzine users. Check the latest studies of Hydroxyzine.

What is Peripheral ischaemia?

Peripheral ischaemia (impaired circulation to an extremity) is found to be associated with 581 drugs and 645 conditions by eHealthMe. Check the latest studies of Peripheral ischaemia.

On Jul, 15, 2026

51,890 people reported to have side effects when taking Hydroxyzine.
Among them, 17 people (0.03%) have Peripheral ischaemia.

Could Hydroxyzine cause Peripheral ischaemia?

Among these 17 people:

What is the gender of people who have Peripheral ischaemia when taking Hydroxyzine? *

female: 80 %
male: 20 %

What is the age of people who have Peripheral ischaemia when taking Hydroxyzine? *

What are other drugs people take besides Hydroxyzine? *

What are other side effects people have besides Peripheral ischaemia? *

Varicose Vein (veins that have become enlarged and tortuous): 6 people, 35.29%
Cardiac Arrest: 5 people, 29.41%
Thrombosis (formation of a blood clot inside a blood vessel): 5 people, 29.41%
Faecal Occult Blood Positive: 3 people, 17.65%
Pneumonia: 2 people, 11.76%
Hemiparesis (weakness on one side of the body): 2 people, 11.76%
Influenza Like Illness: 2 people, 11.76%
Ecchymosis (a discoloration of the skin resulting from bleeding underneath): 2 people, 11.76%
Drug Hypersensitivity: 2 people, 11.76%
Diarrhea Aggravated: 2 people, 11.76%

What are the existing conditions these people have? *

Urticaria (rash of round, red welts on the skin that itch intensely): 6 people, 35.29%
Pain: 6 people, 35.29%
Migraine (headache): 6 people, 35.29%
Bladder Disorder: 5 people, 29.41%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.88%
Leukaemia (blood or bone marrow cancer): 1 person, 5.88%
High Blood Pressure: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Hydroxyzine and have Peripheral ischaemia?

- Check whether Peripheral ischaemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydroxyzine:

Hydroxyzine (54,069 reports)

Browse all side effects of Hydroxyzine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Peripheral ischaemia:

Peripheral ischaemia (581 drugs)

Browse all the conditions that are associated with Peripheral ischaemia:

Peripheral ischaemia (645 conditions)

Related publications that referenced our studies

Ate? ?, Arikan MF, Kaplan M, Altay M, "Hydroxyzine induced pancytopenia and petechial rashes: a rare complication", Journal Of Contemporary Medicine, 2017 Jan .
Ate? ?, Arikan MF, Kaplan M, Altay M, "Hydroxyzine induced pancytopenia and petechial rashes: a rare complication", Journal Of Contemporary Medicine, 2017 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on hydroxyzine hydrochloride (the active ingredients of Hydroxyzine) and Hydroxyzine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.