Hysingla and Agitation - a phase IV clinical study of FDA data

Summary:

Agitation is reported as a side effect among people who take Hysingla (hydrocodone bitartrate), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Hydrocodone Bitartrate And Acetaminophen, and have Pain.

The phase IV clinical study analyzes which people have Agitation when taking Hysingla. It is created by eHealthMe based on reports of 32,589 people who have side effects when taking Hysingla from the FDA, and is updated regularly.

What is Hysingla?

Hysingla has active ingredients of hydrocodone bitartrate. eHealthMe is studying from 32,609 Hysingla users. Check the latest studies of Hysingla.

What is Agitation?

Agitation (state of anxiety or nervous excitement) is found to be associated with 2,281 drugs and 3,318 conditions by eHealthMe. Check the latest studies of Agitation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

32,589 people reported to have side effects when taking Hysingla.
Among them, 25 people (0.08%) have Agitation.

Among these 25 people:

How long have people been on Hysingla when they have Agitation? *

What is the gender of people who have Agitation when taking Hysingla? *

female: 68 %
male: 32 %

What is the age of people who have Agitation when taking Hysingla? *

What are other drugs people take besides Hysingla? *

Hydrocodone Bitartrate And Acetaminophen: 4 people, 16.00%
Oxycontin: 3 people, 12.00%
Oxycodone Hydrochloride: 3 people, 12.00%
Palladone: 2 people, 8.00%
Hydrocodone: 2 people, 8.00%
Dilaudid: 2 people, 8.00%
Dhc Plus: 2 people, 8.00%
Vitamin D: 1 person, 4.00%
Tramadol: 1 person, 4.00%
Ryzolt: 1 person, 4.00%

What are other side effects people have besides Agitation? *

Insomnia (sleeplessness): 7 people, 28.00%
Drug Dependence: 7 people, 28.00%
Hyperhidrosis (abnormally increased sweating): 5 people, 20.00%
Pain: 5 people, 20.00%
Stress And Anxiety: 4 people, 16.00%
Irritability: 4 people, 16.00%
Nausea And Vomiting: 3 people, 12.00%
Headache (pain in head): 3 people, 12.00%
Depression: 3 people, 12.00%
Memory Loss: 3 people, 12.00%

What are the existing conditions these people have? *

Pain: 6 people, 24.00%
Broken Bone: 2 people, 8.00%
Spinal Column Stenosis (narrowing of spinal column): 1 person, 4.00%
Neuralgia (pain in one or more nerves): 1 person, 4.00%
Joint Pain: 1 person, 4.00%
Drug Dependence: 1 person, 4.00%
Breakthrough Pain: 1 person, 4.00%
Back Disorder: 1 person, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Hysingla and have Agitation?

- Check whether Agitation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hysingla:

Hysingla (32,609 reports)

Agitation treatments and more:

Agitation (142,109 reports)

Browse all side effects of Hysingla:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Agitation:

Agitation (2,281 drugs)

Browse all the conditions that are associated with Agitation:

Agitation (3,318 conditions)

Related publications that referenced our studies

Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .
Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on hydrocodone bitartrate (the active ingredients of Hysingla) and Hysingla (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.