Hyzaar and Aortic valve incompetence - a phase IV clinical study of FDA data

Summary:

Aortic valve incompetence is reported as a side effect among people who take Hyzaar (hydrochlorothiazide; losartan potassium), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Vioxx, and have Depression.

The phase IV clinical study analyzes which people have Aortic valve incompetence when taking Hyzaar. It is created by eHealthMe based on reports of 15,960 people who have side effects when taking Hyzaar from the FDA, and is updated regularly.

What is Hyzaar?

Hyzaar has active ingredients of hydrochlorothiazide; losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 16,614 Hyzaar users. Check the latest studies of Hyzaar.

What is Aortic valve incompetence?

Aortic valve incompetence is found to be associated with 921 drugs and 881 conditions by eHealthMe. Check the latest studies of Aortic valve incompetence.

On Jul, 11, 2026

15,960 people reported to have side effects when taking Hyzaar.
Among them, 30 people (0.19%) have Aortic valve incompetence.

Could Hyzaar cause Aortic valve incompetence?

Among these 30 people:

How long have people been on Hyzaar when they have Aortic valve incompetence? *

What is the gender of people who have Aortic valve incompetence when taking Hyzaar? *

female: 43.33 %
male: 56.67 %

What is the age of people who have Aortic valve incompetence when taking Hyzaar? *

What are other drugs people take besides Hyzaar? *

What are other side effects people have besides Aortic valve incompetence? *

Mitral Valve Incompetence (inefficient heart valve): 19 people, 63.33%
Tricuspid Valve Incompetence (inefficient heart valve): 15 people, 50.00%
Fatigue (feeling of tiredness): 14 people, 46.67%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 11 people, 36.67%
Stress And Anxiety: 9 people, 30.00%
Dizziness: 9 people, 30.00%
Cough: 9 people, 30.00%
Chest Pain: 9 people, 30.00%
Pain: 8 people, 26.67%
Dyspnea Exertional: 8 people, 26.67%

What are the existing conditions these people have? *

High Blood Cholesterol: 5 people, 16.67%
Depression: 5 people, 16.67%
Multiple Myeloma (cancer of the plasma cells): 4 people, 13.33%
Joint Pain: 2 people, 6.67%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 6.67%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 6.67%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 6.67%
Asthma: 2 people, 6.67%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 6.67%
Gouty Arthritis (joint inflammation with crystal formation): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Hyzaar and have Aortic valve incompetence?

- Check whether Aortic valve incompetence is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hyzaar:

Hyzaar (16,614 reports)

Aortic valve incompetence treatments and more:

Aortic valve incompetence (8,412 reports)

How severe was Aortic valve incompetence and when was it recovered:

Aortic valve incompetence in Hyzaar

Expand to all the drugs that have ingredients of hydrochlorothiazide; losartan potassium:

Aortic valve incompetence and drugs with ingredients of hydrochlorothiazide; losartan potassium (32 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hyzaar:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aortic valve incompetence:

Aortic valve incompetence (921 drugs)

Browse all the conditions that are associated with Aortic valve incompetence:

Aortic valve incompetence (881 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; losartan potassium (the active ingredients of Hyzaar) and Hyzaar (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.