Hyzaar and Blood creatine increased - a phase IV clinical study of FDA data

Summary:

Blood creatine increased is reported as a side effect among people who take Hyzaar (hydrochlorothiazide; losartan potassium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Aspirin, and have Osteomyelitis.

The phase IV clinical study analyzes which people have Blood creatine increased when taking Hyzaar. It is created by eHealthMe based on reports of 15,960 people who have side effects when taking Hyzaar from the FDA, and is updated regularly.

What is Hyzaar?

Hyzaar has active ingredients of hydrochlorothiazide; losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 16,614 Hyzaar users. Check the latest studies of Hyzaar.

What is Blood creatine increased?

Blood creatine increased is found to be associated with 637 drugs and 681 conditions by eHealthMe. Check the latest studies of Blood creatine increased.

On Jul, 13, 2026

15,960 people reported to have side effects when taking Hyzaar.
Among them, 19 people (0.12%) have Blood creatine increased.

Could Hyzaar cause Blood creatine increased?

Among these 19 people:

How long have people been on Hyzaar when they have Blood creatine increased? *

What is the gender of people who have Blood creatine increased when taking Hyzaar? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Blood creatine increased when taking Hyzaar? *

What are other drugs people take besides Hyzaar? *

What are other side effects people have besides Blood creatine increased? *

Hypokalemia (low potassium): 6 people, 31.58%
Anaemia (lack of blood): 5 people, 26.32%
Infection: 5 people, 26.32%
Sepsis (a severe blood infection that can lead to organ failure and death): 5 people, 26.32%
Pleural Disorder: 5 people, 26.32%
Fatigue (feeling of tiredness): 4 people, 21.05%
Blood Urea Increased: 4 people, 21.05%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 4 people, 21.05%
Fever: 3 people, 15.79%
Pleural Effusion (water on the lungs): 3 people, 15.79%

What are the existing conditions these people have? *

Osteomyelitis (infection of bone): 5 people, 26.32%
High Blood Cholesterol: 2 people, 10.53%
Staphylococcal Infection (an infection with staphylococcus bacteria): 1 person, 5.26%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 5.26%
Pancreatic Neuroendocrine Tumor: 1 person, 5.26%
Multiple Myeloma (cancer of the plasma cells): 1 person, 5.26%
Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 1 person, 5.26%
Essential Hypertension (primary hypertension): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Hyzaar and have Blood creatine increased?

- Check whether Blood creatine increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hyzaar:

Hyzaar (16,614 reports)

Blood creatine increased treatments and more:

Blood creatine increased (6,377 reports)

How severe was Blood creatine increased and when was it recovered:

Blood creatine increased in Hyzaar

Expand to all the drugs that have ingredients of hydrochlorothiazide; losartan potassium:

Blood creatine increased and drugs with ingredients of hydrochlorothiazide; losartan potassium

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hyzaar:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Blood creatine increased:

Blood creatine increased (637 drugs)

Browse all the conditions that are associated with Blood creatine increased:

Blood creatine increased (681 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; losartan potassium (the active ingredients of Hyzaar) and Hyzaar (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.