Ifex and Death - a phase IV clinical study of FDA data

Summary:

Death is reported as a side effect among people who take Ifex (ifosfamide), especially for people who are male, 60+ old, also take Methotrexate, and have Burkitt's lymphoma.

The study is created by eHealthMe based on reports of 827 people who have side effects when taking Ifex from the FDA, and is updated regularly.

What is Ifex?

Ifex has active ingredients of ifosfamide. eHealthMe is studying from 829 Ifex users. Check the latest studies of Ifex.

On Aug, 03, 2026

827 people reported to have side effects when taking Ifex.
Among them, 13 people (1.57%) died.

Among these 13 people:

What is the gender of people who died when taking Ifex? *

female: 27.27 %
male: 72.73 %

What is the age of people who died when taking Ifex? *

What are other drugs people take besides Ifex? *

What are other side effects people have before they died? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 3 people, 23.08%
Dyspnea (difficult or laboured breathing): 3 people, 23.08%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 3 people, 23.08%
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system): 2 people, 15.38%
Fatigue (feeling of tiredness): 2 people, 15.38%
Jugular Vein Thrombosis (clot in jugular vein): 2 people, 15.38%
Myelitis (infection or the inflammation of white matter or gray matter of spinal cord which is a part of central nervous system): 2 people, 15.38%
Neoplasm Malignant (cancer tumour): 2 people, 15.38%
Graft Loss (graft failure): 2 people, 15.38%
Carbon Dioxide Decreased: 2 people, 15.38%

What are the existing conditions these people have? *

Burkitt's Lymphoma (cancer of the lymphatic system): 3 people, 23.08%
Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 2 people, 15.38%
Synovial Sarcoma (tumour of synovial membrane of joint): 1 person, 7.69%
Renal Cell Carcinoma (a kidney cancer): 1 person, 7.69%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 1 person, 7.69%
Malignant Lymphoid Neoplasm (malignant growth or tumour caused by abnormal and uncontrolled cell division in lymph node): 1 person, 7.69%
Leiomyosarcoma (a very rare soft tissue sarcoma (cancer) that grows in muscle tissue): 1 person, 7.69%
Hiv Infection: 1 person, 7.69%
Gastrointestinal Carcinoma (cancer of stomach or intestine): 1 person, 7.69%
Brain Neoplasm Malignant (brain cancer tumour): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ifex:

Ifex (829 reports)

Expand to all the drugs that have ingredients of ifosfamide:

Death and drugs with ingredients of ifosfamide (600 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ifex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Death:

Death (3,115 drugs)

Browse all the conditions that are associated with Death:

Death (3,686 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ifosfamide (the active ingredients of Ifex) and Ifex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.