Imodium a-d and Lower limb fracture - a phase IV clinical study of FDA data

Summary:

Lower limb fracture is reported as a side effect among people who take Imodium a-d (loperamide hydrochloride), especially for people who are female, 60+ old, also take Xyrem, and have Narcolepsy.

The phase IV clinical study analyzes which people have Lower limb fracture when taking Imodium a-d. It is created by eHealthMe based on reports of 8,753 people who have side effects when taking Imodium a-d from the FDA, and is updated regularly.

What is Imodium a-d?

Imodium a-d has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 8,944 Imodium a-d users. Check the latest studies of Imodium a-d.

What is Lower limb fracture?

Lower limb fracture is found to be associated with 1,004 drugs and 889 conditions by eHealthMe. Check the latest studies of Lower limb fracture.

On Aug, 07, 2026

8,753 people reported to have side effects when taking Imodium a-d.
Among them, 15 people (0.17%) have Lower limb fracture.

$Could Imodium a-d cause Lower limb fracture?$

Among these 15 people:

What is the gender of people who have Lower limb fracture when taking Imodium a-d? *

female: 69.23 %
male: 30.77 %

What is the age of people who have Lower limb fracture when taking Imodium a-d? *

What are other drugs people take besides Imodium a-d? *

What are other side effects people have besides Lower limb fracture? *

Fall: 8 people, 53.33%
Fatigue (feeling of tiredness): 5 people, 33.33%
Lung Neoplasm Malignant (cancer tumour of lung): 5 people, 33.33%
Haemorrhage (bleeding): 4 people, 26.67%
Muscle Spasms (muscle contraction): 3 people, 20.00%
Appetite - Increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 3 people, 20.00%
Indigestion: 3 people, 20.00%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 3 people, 20.00%
Weight Decreased: 2 people, 13.33%
Food Craving: 2 people, 13.33%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 40.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 26.67%
Multiple Myeloma (cancer of the plasma cells): 3 people, 20.00%
Insomnia (sleeplessness): 3 people, 20.00%
Primary Myelofibrosis (primary disorder of the bone marrow): 2 people, 13.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 6.67%
Drowsiness: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Imodium a-d and have Lower limb fracture?

- Check whether Lower limb fracture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Imodium a-d:

Imodium a-d (8,944 reports)

Browse all side effects of Imodium a-d:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Lower limb fracture:

Lower limb fracture (1,004 drugs)

Browse all the conditions that are associated with Lower limb fracture:

Lower limb fracture (889 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on loperamide hydrochloride (the active ingredients of Imodium a-d) and Imodium a-d (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.