Imodium a-d and Oedema - a phase IV clinical study of FDA data

Summary:

Oedema is reported as a side effect among people who take Imodium a-d (loperamide hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Prilosec, and have Nausea.

The phase IV clinical study analyzes which people have Oedema when taking Imodium a-d. It is created by eHealthMe based on reports of 8,753 people who have side effects when taking Imodium a-d from the FDA, and is updated regularly.

What is Imodium a-d?

Imodium a-d has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 8,944 Imodium a-d users. Check the latest studies of Imodium a-d.

What is Oedema?

Oedema (fluid collection in tissue) is found to be associated with 2,159 drugs and 2,311 conditions by eHealthMe. Check the latest studies of Oedema.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

8,753 people reported to have side effects when taking Imodium a-d.
Among them, 37 people (0.42%) have Oedema.

Among these 37 people:

How long have people been on Imodium a-d when they have Oedema? *

What is the gender of people who have Oedema when taking Imodium a-d? *

female: 72.97 %
male: 27.03 %

What is the age of people who have Oedema when taking Imodium a-d? *

What are other drugs people take besides Imodium a-d? *

What are other side effects people have besides Oedema? *

Weakness: 9 people, 24.32%
Dyspnea (difficult or laboured breathing): 8 people, 21.62%
Cardiac Failure Congestive: 8 people, 21.62%
High Blood Pressure: 7 people, 18.92%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 18.92%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 16.22%
Depression: 6 people, 16.22%
Rashes (redness): 6 people, 16.22%
Pain: 6 people, 16.22%
Asthma: 6 people, 16.22%

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 7 people, 18.92%
High Blood Cholesterol: 5 people, 13.51%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 13.51%
Nausea And Vomiting: 5 people, 13.51%
Muscle Spasms (muscle contraction): 4 people, 10.81%
Constipation: 4 people, 10.81%
Discomfort: 4 people, 10.81%
Dyspnea (difficult or laboured breathing): 4 people, 10.81%
Fever: 4 people, 10.81%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 10.81%

* Approximation only. Some reports may have incomplete information.

Do you take Imodium a-d and have Oedema?

- Check whether Oedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Imodium a-d:

Imodium a-d (8,944 reports)

Oedema treatments and more:

Oedema (78,747 reports)

Browse all side effects of Imodium a-d:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Oedema:

Oedema (2,159 drugs)

Browse all the conditions that are associated with Oedema:

Oedema (2,311 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on loperamide hydrochloride (the active ingredients of Imodium a-d) and Imodium a-d (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.