Imodium multi-symptom relief and Flatulence - a phase IV clinical study of FDA data

Summary:

Flatulence is reported as a side effect among people who take Imodium multi-symptom relief (loperamide hydrochloride; simethicone), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Imodium A-D, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Flatulence when taking Imodium multi-symptom relief. It is created by eHealthMe based on reports of 5,444 people who have side effects when taking Imodium multi-symptom relief from the FDA, and is updated regularly.

What is Imodium multi-symptom relief?

Imodium multi-symptom relief has active ingredients of loperamide hydrochloride; simethicone. It is often used in diarrhea. eHealthMe is studying from 5,486 Imodium multi-symptom relief users. Check the latest studies of Imodium multi-symptom relief.

What is Flatulence?

Flatulence (flatus expelled through the anus) is found to be associated with 1,755 drugs and 1,894 conditions by eHealthMe. Check the latest studies of Flatulence.

On Aug, 11, 2026

5,444 people reported to have side effects when taking Imodium multi-symptom relief.
Among them, 74 people (1.36%) have Flatulence.

Could Imodium multi-symptom relief cause Flatulence?

Among these 74 people:

How long have people been on Imodium multi-symptom relief when they have Flatulence? *

What is the gender of people who have Flatulence when taking Imodium multi-symptom relief? *

female: 64.62 %
male: 35.38 %

What is the age of people who have Flatulence when taking Imodium multi-symptom relief? *

What are other drugs people take besides Imodium multi-symptom relief? *

What are other side effects people have besides Flatulence? *

Drug Ineffective: 24 people, 32.43%
Abdominal Distension: 17 people, 22.97%
Constipation: 9 people, 12.16%
Muscle Spasms (muscle contraction): 8 people, 10.81%
Abdominal Pain Upper: 7 people, 9.46%
Dizziness: 4 people, 5.41%
Abdominal Pain: 4 people, 5.41%
Nausea (feeling of having an urge to vomit): 4 people, 5.41%
Fatigue (feeling of tiredness): 3 people, 4.05%
Overdose: 3 people, 4.05%

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 6.76%
Thyroid Diseases: 3 people, 4.05%
High Blood Pressure: 3 people, 4.05%
High Blood Cholesterol: 3 people, 4.05%
Abdominal Distension: 3 people, 4.05%
Migraine (headache): 2 people, 2.70%
Cardiac Disorder: 2 people, 2.70%
Depression: 2 people, 2.70%
Nausea And Vomiting: 1 person, 1.35%
Diabetes: 1 person, 1.35%

* Approximation only. Some reports may have incomplete information.

Do you take Imodium multi-symptom relief and have Flatulence?

- Check whether Flatulence is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Imodium multi-symptom relief:

Imodium multi-symptom relief (5,486 reports)

Flatulence treatments and more:

Flatulence (70,667 reports)

How severe was Flatulence and when was it recovered:

Flatulence in Imodium multi-symptom relief

Expand to all the drugs that have ingredients of loperamide hydrochloride; simethicone:

Flatulence and drugs with ingredients of loperamide hydrochloride; simethicone

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Imodium multi-symptom relief:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Flatulence:

Flatulence (1,755 drugs)

Browse all the conditions that are associated with Flatulence:

Flatulence (1,894 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on loperamide hydrochloride; simethicone (the active ingredients of Imodium multi-symptom relief) and Imodium multi-symptom relief (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.