Imodium and Bile acid malabsorption - a phase IV clinical study of FDA data

Summary:

Bile acid malabsorption is reported as a side effect among people who take Imodium (loperamide hydrochloride), especially for people who are female, 30-39 old, also take Escitalopram, and have Depression.

The phase IV clinical study analyzes which people have Bile acid malabsorption when taking Imodium. It is created by eHealthMe based on reports of 44,210 people who have side effects when taking Imodium from the FDA, and is updated regularly.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,092 Imodium users. Check the latest studies of Imodium.

What is Bile acid malabsorption?

Bile acid malabsorption is found to be associated with 29 drugs and 77 conditions by eHealthMe. Check the latest studies of Bile acid malabsorption.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

44,210 people reported to have side effects when taking Imodium.
Among them, 15 people (0.03%) have Bile acid malabsorption.

Could Imodium cause Bile acid malabsorption?

Among these 15 people:

What is the gender of people who have Bile acid malabsorption when taking Imodium? *

female: 86.67 %
male: 13.33 %

What is the age of people who have Bile acid malabsorption when taking Imodium? *

What are other drugs people take besides Imodium? *

Escitalopram: 12 people, 80.00%
Questran: 10 people, 66.67%
Pantoprazole: 8 people, 53.33%
Spironolactone: 5 people, 33.33%
Colesevelam Hydrochloride: 5 people, 33.33%
Entyvio: 5 people, 33.33%
Lamotrigine: 5 people, 33.33%
Levetiracetam: 5 people, 33.33%
Mercaptopurine: 5 people, 33.33%
Cholestyramine: 5 people, 33.33%

What are other side effects people have besides Bile acid malabsorption? *

Abdominal Pain: 12 people, 80.00%
Functional Gastrointestinal Disorder (functional problem in separate organs of gastrointestinal system): 12 people, 80.00%
Clostridium Difficile Colitis (inflammation of colon by clostridium difficile bacteria infection): 11 people, 73.33%
Drug Ineffective: 11 people, 73.33%
Therapeutic Response Decreased (less preventive response): 6 people, 40.00%
Vitamin B12 Decreased: 1 person, 6.67%
Glucose Tolerance Impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis): 1 person, 6.67%
Arthritis Enteropathic (form of chronic, inflammatory arthritis associated with the occurrence of an inflammatory bowel disease): 1 person, 6.67%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 6.67%
Chronic Kidney Disease: 1 person, 6.67%

What are the existing conditions these people have? *

Depression: 12 people, 80.00%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 11 people, 73.33%
Myoclonic Epilepsy (type of epilepsy with quick little jerks of the arms, shoulder, or occasionally the legs): 8 people, 53.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 6.67%
Pain: 1 person, 6.67%
Multiple Myeloma (cancer of the plasma cells): 1 person, 6.67%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 6.67%
Hypokalemia (low potassium): 1 person, 6.67%
Essential Hypertension (primary hypertension): 1 person, 6.67%
Erection Problems: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Imodium and have Bile acid malabsorption?

- Check whether Bile acid malabsorption is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Imodium:

Imodium (45,092 reports)

Browse all side effects of Imodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bile acid malabsorption:

Bile acid malabsorption (29 drugs)

Browse all the conditions that are associated with Bile acid malabsorption:

Bile acid malabsorption (77 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on loperamide hydrochloride (the active ingredients of Imodium) and Imodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.