Imodium and Bone loss - a phase IV clinical study of FDA data

Summary:

Bone loss is reported as a side effect among people who take Imodium (loperamide hydrochloride), especially for people who are female, 50-59 old, also take Zometa, and have Osteoporosis.

The phase IV clinical study analyzes which people have Bone loss when taking Imodium. It is created by eHealthMe based on reports of 44,210 people who have side effects when taking Imodium from the FDA, and is updated regularly.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,092 Imodium users. Check the latest studies of Imodium.

What is Bone loss?

Bone loss is found to be associated with 698 drugs and 557 conditions by eHealthMe. Check the latest studies of Bone loss.

On Jul, 06, 2026

44,210 people reported to have side effects when taking Imodium.
Among them, 65 people (0.15%) have Bone loss.

Among these 65 people:

What is the gender of people who have Bone loss when taking Imodium? *

female: 78.12 %
male: 21.88 %

What is the age of people who have Bone loss when taking Imodium? *

What are other drugs people take besides Imodium? *

What are other side effects people have besides Bone loss? *

Pain: 61 people, 93.85%
Stress And Anxiety: 57 people, 87.69%
Osteonecrosis Of Jaw (death of bone of jaw): 54 people, 83.08%
Back Pain: 43 people, 66.15%
Osteoporosis (bones weak and more likely to break): 39 people, 60.00%
Injury: 38 people, 58.46%
Dyspnea (difficult or laboured breathing): 38 people, 58.46%
Exposed Bone In Jaw: 36 people, 55.38%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 34 people, 52.31%
Anaemia (lack of blood): 31 people, 47.69%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 15 people, 23.08%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 13 people, 20.00%
Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 13 people, 20.00%
Multiple Myeloma (cancer of the plasma cells): 13 people, 20.00%
Pain: 8 people, 12.31%
Dyspnea (difficult or laboured breathing): 6 people, 9.23%
Osteopenia (a condition where bone mineral density is lower than normal): 6 people, 9.23%
High Blood Cholesterol: 6 people, 9.23%
Arthropod Sting (arthropod bite): 6 people, 9.23%
Breast Cancer: 5 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Imodium and have Bone loss?

- Check whether Bone loss is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Imodium:

Imodium (45,092 reports)

Bone loss treatments and more:

Bone loss (27,142 reports)

Browse all side effects of Imodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bone loss:

Bone loss (698 drugs)

Browse all the conditions that are associated with Bone loss:

Bone loss (557 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on loperamide hydrochloride (the active ingredients of Imodium) and Imodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.