Imuran and Injection site nodule - a phase IV clinical study of FDA data

Summary:

Injection site nodule is reported as a side effect among people who take Imuran (azathioprine), especially for people who are female, 50-59 old, also take Humira, and have Hypothyroidism.

The phase IV clinical study analyzes which people have Injection site nodule when taking Imuran. It is created by eHealthMe based on reports of 34,190 people who have side effects when taking Imuran from the FDA, and is updated regularly.

What is Imuran?

Imuran has active ingredients of azathioprine. It is often used in crohn's disease. eHealthMe is studying from 34,915 Imuran users. Check the latest studies of Imuran.

What is Injection site nodule?

Injection site nodule (small swelling or aggregation of cells in the body, esp. an abnormal one at injection site) is found to be associated with 413 drugs and 588 conditions by eHealthMe. Check the latest studies of Injection site nodule.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

34,190 people reported to have side effects when taking Imuran.
Among them, 26 people (0.08%) have Injection site nodule.

Could Imuran cause Injection site nodule?

Among these 26 people:

What is the gender of people who have Injection site nodule when taking Imuran? *

female: 69.23 %
male: 30.77 %

What is the age of people who have Injection site nodule when taking Imuran? *

What are other drugs people take besides Imuran? *

What are other side effects people have besides Injection site nodule? *

Injection Site Pain: 12 people, 46.15%
Injection Site Erythema (redness at injection site): 9 people, 34.62%
Injection Site Haemorrhage (bleeding from injection site): 8 people, 30.77%
Injection Site Pruritus (severe itching at injection site): 6 people, 23.08%
High Blood Pressure: 4 people, 15.38%
Injection Site Warmth: 3 people, 11.54%
Fatigue (feeling of tiredness): 3 people, 11.54%
Weakness: 2 people, 7.69%
Injection Site Swelling: 2 people, 7.69%
Injection Site Reaction: 2 people, 7.69%

What are the existing conditions these people have? *

High Blood Pressure: 5 people, 19.23%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 19.23%
Stress And Anxiety: 2 people, 7.69%
Osteoporosis (bones weak and more likely to break): 2 people, 7.69%
Depression: 2 people, 7.69%
Headache (pain in head): 2 people, 7.69%
Hypersensitivity: 2 people, 7.69%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 7.69%
Indigestion: 2 people, 7.69%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Imuran and have Injection site nodule?

- Check whether Injection site nodule is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Imuran:

Imuran (34,915 reports)

Browse all side effects of Imuran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Injection site nodule:

Injection site nodule (413 drugs)

Browse all the conditions that are associated with Injection site nodule:

Injection site nodule (588 conditions)

Related publications that referenced our studies

Almarshad HA, "Effect of ginger rhizome extract on lymphocytopenic guinea pig with azathioprine", African Journal of Pharmacy and Pharmacology, 2014 Nov .
Almarshad HA, "Effect of ginger rhizome extract on lymphocytopenic guinea pig with azathioprine", African Journal of Pharmacy and Pharmacology, 2014 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on azathioprine (the active ingredients of Imuran) and Imuran (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.