Inderal and Major depression - a phase IV clinical study of FDA data

Summary:

Major depression is reported as a side effect among people who take Inderal (propranolol hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 10+ years also take Phenergan, and have Pain.

The phase IV clinical study analyzes which people have Major depression when taking Inderal. It is created by eHealthMe based on reports of 15,491 people who have side effects when taking Inderal from the FDA, and is updated regularly.

What is Inderal?

Inderal has active ingredients of propranolol hydrochloride. It is often used in migraine. eHealthMe is studying from 16,771 Inderal users. Check the latest studies of Inderal.

What is Major depression?

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings) is found to be associated with 804 drugs and 1,475 conditions by eHealthMe. Check the latest studies of Major depression.

On Apr, 10, 2026

15,491 people reported to have side effects when taking Inderal.
Among them, 18 people (0.12%) have Major depression.

Among these 18 people:

How long have people been on Inderal when they have Major depression? *

What is the gender of people who have Major depression when taking Inderal? *

female: 61.11 %
male: 38.89 %

What is the age of people who have Major depression when taking Inderal? *

What are other drugs people take besides Inderal? *

What are other side effects people have besides Major depression? *

Suicidal Ideation: 7 people, 38.89%
Suicide Attempt: 6 people, 33.33%
Weakness: 4 people, 22.22%
Irritability: 4 people, 22.22%
Depression: 3 people, 16.67%
Overdose: 3 people, 16.67%
Cough: 3 people, 16.67%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 16.67%
Precocious Puberty: 3 people, 16.67%
Sinusitis (inflammation of sinus): 3 people, 16.67%

What are the existing conditions these people have? *

Pain: 5 people, 27.78%
Tremor (trembling or shaking movements in one or more parts of your body): 4 people, 22.22%
Affective Disorder (mental disorder): 3 people, 16.67%
Bipolar Ii Disorder (characterized by at least one episode of hypomania and at least one episode of major depression): 3 people, 16.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 16.67%
Insomnia (sleeplessness): 3 people, 16.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 16.67%
Nausea (feeling of having an urge to vomit): 2 people, 11.11%
Drowsiness: 2 people, 11.11%
Sleep Disorder: 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Inderal and have Major depression?

- Check whether Major depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Inderal:

Inderal (16,771 reports)

Major depression treatments and more:

Major depression (44,979 reports)

Browse all side effects of Inderal:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Major depression:

Major depression (804 drugs)

Browse all the conditions that are associated with Major depression:

Major depression (1,475 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on propranolol hydrochloride (the active ingredients of Inderal) and Inderal (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.